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Table 3 Correlation matrix demonstrating associations between changes in inflammatory parameters and structural lesions on MRI in patients with axial spondyloarthritis receiving either standard or TNFα inhibitor therapy

From: Tumor necrosis factor inhibitor therapy but not standard therapy is associated with resolution of erosion in the sacroiliac joints of patients with axial spondyloarthritis

TNFα inhibitor therapy (n= 79) Standard therapy (n= 68)
  CRP ASDAS SPARCC MRI SIJ inflammation score SSS for fat metaplasia SSS for erosion SSS for backfill SSS for ankylosis
CRP   0.27, P = 0.05 0.19, P = 0.NS 0.13, P = 0.NS 0.16, P = NS −0.03, P = NS −0.19, P = NS
ASDAS 0.27, P = 0.042   0.15, P = NS −0.04, P = NS 0.20, P = NS −0.12, P = NS −0.23, P = NS
SPARCC MRI SIJ inflammation score 0.12, P = NS 0.12, P = NS   −0.28, P = 0.041 0.29, P = 0.032 −0.34, P = 0.011 −0.02, P = NS
SSS for fat metaplasia −0.27, P = 0.023 −0.07, P = NS −0.40, P = 0.001   −0.08, P = NS 0.31, P = 0.0097 0.21, P = 0.092
SSS for erosion 0.023, P = NS −0.23, P = NS 0.49, P < 0.0001 −0.54, P < 0.0001   −0.39, P = 0.0011 −0.33, P = 0.0058
SSS for backfill −0.11, P = NS 0.04, P = NS −0.39, P = 0.001 0.30, P = 0.008 −0.46 < 0.0001   −0.02, P = NS
SSS for ankylosis 0.10, P = NS 0.07, P = NS −0.09, P = NS 0.35, P = 0.0018 −0.33, P = 0.0027 0.06, P = NS  
  1. Data presented as Spearman’s rho and P values. Data in bold are statistically significant. ASDAS, Ankylosing Spondylitis Disease Activity Score; CRP, C-reactive protein; MRI, magnetic resonance imaging; NS, not significant; SIJ, sacroiliac joint; SPARCC, Spondyloarthritis Research Consortium of Canada; SSS, Sacroiliac Joint Structural Score; TNFα, tumor necrosis factor alpha.