Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers

Table 3 Future research requirements for the most promising non-classification laboratory assays

Test	Assay	Future research needs
Anti-DI antibodies	ELISA	Analytical and post-analytical standardization
Anti-DI antibodies	CIA	Retrospective and prospective clinical validation
Anti-PS/PT antibodies	ELISA	Analytical and post-analytical standardization
Anti-PS/PT antibodies	ELISA	Retrospective confirmatory studies and prospective clinical validation
Anti-PE antibodies	ELISA	Analytical and post-analytical standardization
Anti-PE antibodies	ELISA	Retrospective confirmatory studies and prospective clinical validation
Annexin A5 resistance assay	Two-step coagulation assay	Analytical and post-analytical standardization
		Retrospective and prospective clinical validation

CIA, chemiluminescence immunoassay; DI, domain I; ELISA, enzyme-linked immunosorbent assay; PE, phosphatidylethanolamine; PS/PT, phosphatidylserine-prothrombin.

ISSN: 1478-6362