Figure 2

Scatterplots show minimal or no relationship of serum CXCL13 to high-sensitivity C-reactive protein or disease activity score in 28 joints C-reactive protein in the seropositive groups of the Dartmouth RA Cohort and the Sherbrooke Early Undifferentiated PolyArthritis Cohort. (A) In the Dartmouth RA Cohort, correlation analysis of log-transformed C-X-C motif chemokine 13 (LogCXCL13) and high-sensitivity C-reactive protein (LogCRP) does not show a relationship (n = 123, P = 0.07). (B) In the Dartmouth RA Cohort, correlation analysis of CXCL13 has a modest relationship with Disease Activity Score in 28 joints CRP (DAS28-CRP) (n = 23, P = 0.01). (C) In the recent-onset rheumatoid arthritis (RA) patients from the Sherbrooke Early Undifferentiated PolyArthritis (EUPA) Cohort, no relationship is identified between LogCXCL13 and LogCRP (n = 173, P = 0.08). (D) In the recent-onset RA patients from the Sherbrooke EUPA Cohort, no relationship is identified between LogCXCL13 and DAS28-CRP (n = 170, P = 0.28). Diagonal lines represent lines of best fit.