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Table 1 Patients in the Dartmouth RA Cohort a

From: Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels

Patient demographics (N= 193) Seronegative Seropositive
Number of patients (%) 30 (16%) 163 (84%)
Average age, yr (range) 55.6 (29 to 72) 57.9 (19 to 92)
Females, n (%) 24 (80%) 115 (71%)
RA duration <2 yr 10 (33%) 41 (25%)
SE status, n 14 116
  SE alleles = 0 7 22
  SE alleles = 1 7 56
  SE alleles = 2 0 38
C4 status, n 14 111
  C4 copies <4 9 30
  C4 copies ≥4 5 81
Medication history, n   
  No DMARDs 9 36
  Nonbiologic DMARDs 10 54
  TNF inhibitors 4 42
  Other biologics 7b 31c
  1. aC4, Complement 4; DMARD, Disease-modifying antirheumatic drug; RA, Rheumatoid arthritis; SE, Shared epitope; TNF, Tumor necrosis factor. bAbatacept (n = 1) and rituximab (n = 6). cAbatacept (n = 2), rituximab (n = 27), tocilizumab (n = 1) and tofacitinib (n = 1).