Increased proportions of CD4+CD25-Foxp3+T cells in patients with renal manifestation. Systemic lupus erythematosus (SLE) patients were divided into different groups according to their organ manifestations. In addition patients were subdivided into groups with (active) and without (no active) organ involvement and at the time of the patient’s blood draw. A significant increase in proportions of CD4+CD25-Foxp3+ T cells was observed in patients with renal manifestation (P = 0.005) and in patients with active nephritis (P = 0.005). Increased proportions of CD4+CD25-Foxp3+ T cells were also observed in patients with active hematologic manifestations as compared to patients with no active hematologic manifestations (P = 0.02). *Significant differences.