The allele model meta-analysis for rs7044343. A meta-analysis of discovery, validation, and replication panels confirmed the association between the CC genotype of rs7044343 and RA (Pcombined = 0.0004; ORcombined = 0.77; 95% CI, 0.67 to 0.89). No evidence was found for heterogeneity between three sample sets (P
= 0.99; I2 = 0) (a). Similar results were also obtained in ACPA-negative RA (Pcombined = 0.0002; ORcombined = 0.57; 95% CI, 0.43 to 0.77) (b).