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Table 2 Association analysis of rs7044343 with RA in the discovery population

From: Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis

Characteristic ( n) Allele frequency (%) Genotype frequency (%) T versus C CC versus TT + TC CC + TC versus TT
T C TT TC CC OR (95% CI) OR (95% CI) OR (95% CI)
P value P value P value
Control (598) 545 (45.6) 651 (54.4) 137 (22.9) 271 (45.3) 190 (31.8)    
RA (700) 641 (45.8) 759 (54.2) 127 (18.1) 387 (55.3) 186 (26.6) 1.009 0.777 1.354
(0.864-1.178) (0.611-0.988) (1.033-1.774)
0.912 0.040* 0.028*
RF + (418) 377 (45.1) 459 (54.9) 78 (18.7) 221 (52.9) 119 (28.5) 0.981 0.855 1.308
(0.822-1.172) (0.650-1.123) (0.958-1.785)
0.833 0.260 0.091
RF- (94) 86 (45.7) 102 (54.3) 17 (18.1) 52 (55.3) 25 (26.6) 1.007 0.778 1.359
(0.740-1.371) (0.477-1.269) (0.777-2.376)
0.964 0.314 0.282
ACP (300) 281 (46.8) 319 (53.2) 62 (20.7) 157 (52.3) 81 (27.0) 1.052 0.794 1.152
(0.864-1.281) (0.584-1.080) (0.821-1.615)
0.612 0.142 0.413
ACPA - (113) 108 (47.8) 118 (52.2) 20 (17.7) 68 (60.2) 25 (22.1) 1.093 0.610 1.395
(0.822-1.453) (0.379-0.982) (0.830-2.345)
0.539 0.042* 0.209
Female control (465) 432 (46.5) 498 (53.5) 106 (22.8) 220 (47.3) 139 (29.9)    
Female RA (482) 426 (44.2) 538 (55.8) 85 (17.6) 256 (53.1) 141 (29.3) 0.913 0.970 1.396
(0.762-1.094) (0.734-1.282) (1.015-1.920)
0.323 0.829 0.040
Female RF+ (333) 300 (45.0) 366 (55.0) 62 (18.6) 176 (52.9) 95 (28.5) 0.945 0.936 1.306
(0.774-1.154) (0.687-1.276) (0.920-1.855)
0.578 0.676 0.135
Female RF- (75) 64 (42.7) 86 (57.3) 12 (16.0) 40 (53.3) 23 (30.7) 0.858 1.037 1.569
(0.606-1.215) (0.611-1.761) (0.816-3.018)
0.388 0.892 0.177
Female ACPA+ (243) 225 (46.3) 261 (53.7) 50 (20.6) 125 (51.4) 68 (28.0) 0.994 0.911 1.154
(0.798-1.238) (0.647-1.285) (0.790-1.685)
    0.956 0.596 0.459
Female ACPA- (84) 77 (45.8) 91 (54.2) 15 (17.9) 47 (56.0) 22 (26.2) 0.975 0.832 1.375
(0.701-1.356) (0.492-1.407) (0.756-2.502)
0.882 0.493 0.297
Male CON (105) 99 (47.1) 111 (52.9) 26 (24.8) 47 (44.8) 32 (30.5)    
Male RA (121) 116 (47.9) 126 (52.1) 24 (19.8) 68 (56.2) 29 (24.0) 1.032 0.719 1.330
(0.713-1.495) (0.399-1.296) (0.709-2.496)
0.867 0.272 0.374
Male RF+ (84) 75 (44.6) 93 (55.4) 15 (17.9) 45 (53.6) 24 (28.6) 0.904 0.913 1.514
(0.602-1.359) (0.486-1.713) (0.742-3.088)
0.628 0.776 0.254
Male RF- (19) 22 (57.9) 16 (42.1) 5 (26.3) 12 (63.2) 2 (10.5) 1.542 0.268 0.922
(0.767-3.100) (0.059-1.231) (0.303-2.805)
0.222 0.090 0.886
Male ACPA+ (57) 56 (49.1) 58 (50.9) 12 (21.1) 32 (56.1) 13 (22.8) 1.083 0.674 1.234
(0.686-1.709) (0.320-1.420) (0.568-2.681)
0.733 0.300 0.595
Male ACPA- (27) 29 (53.7) 25 (46.3) 5 (18.5) 19 (70.4) 3 (11.1) 1.301 0.285 1.448
(0.714-2.369) (0.080-1.016) (0.498-4.211)
0.390 0.053 0.497
  1. *P < 0.05 versus controls; ACPAs, anti-citrullinated proteins antibodies; CI, confidence interval.
  2. CON, healthy control; OR, odds ratio; RA, rheumatoid arthritis; RF, rheumatoid factor.