Table 2 Association analysis of rs7044343 with RA in the discovery population
From: Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis
Characteristic ( n) | Allele frequency (%) | Genotype frequency (%) | T versus C | CC versus TT + TC | CC + TC versus TT | |||
|---|---|---|---|---|---|---|---|---|
T | C | TT | TC | CC | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
P value | P value | P value | ||||||
Control (598) | 545 (45.6) | 651 (54.4) | 137 (22.9) | 271 (45.3) | 190 (31.8) | |||
RA (700) | 641 (45.8) | 759 (54.2) | 127 (18.1) | 387 (55.3) | 186 (26.6) | 1.009 | 0.777 | 1.354 |
(0.864-1.178) | (0.611-0.988) | (1.033-1.774) | ||||||
0.912 | 0.040* | 0.028* | ||||||
RF + (418) | 377 (45.1) | 459 (54.9) | 78 (18.7) | 221 (52.9) | 119 (28.5) | 0.981 | 0.855 | 1.308 |
(0.822-1.172) | (0.650-1.123) | (0.958-1.785) | ||||||
0.833 | 0.260 | 0.091 | ||||||
RF- (94) | 86 (45.7) | 102 (54.3) | 17 (18.1) | 52 (55.3) | 25 (26.6) | 1.007 | 0.778 | 1.359 |
(0.740-1.371) | (0.477-1.269) | (0.777-2.376) | ||||||
0.964 | 0.314 | 0.282 | ||||||
ACP (300) | 281 (46.8) | 319 (53.2) | 62 (20.7) | 157 (52.3) | 81 (27.0) | 1.052 | 0.794 | 1.152 |
(0.864-1.281) | (0.584-1.080) | (0.821-1.615) | ||||||
0.612 | 0.142 | 0.413 | ||||||
ACPA - (113) | 108 (47.8) | 118 (52.2) | 20 (17.7) | 68 (60.2) | 25 (22.1) | 1.093 | 0.610 | 1.395 |
(0.822-1.453) | (0.379-0.982) | (0.830-2.345) | ||||||
0.539 | 0.042* | 0.209 | ||||||
Female control (465) | 432 (46.5) | 498 (53.5) | 106 (22.8) | 220 (47.3) | 139 (29.9) | |||
Female RA (482) | 426 (44.2) | 538 (55.8) | 85 (17.6) | 256 (53.1) | 141 (29.3) | 0.913 | 0.970 | 1.396 |
(0.762-1.094) | (0.734-1.282) | (1.015-1.920) | ||||||
0.323 | 0.829 | 0.040 | ||||||
Female RF+ (333) | 300 (45.0) | 366 (55.0) | 62 (18.6) | 176 (52.9) | 95 (28.5) | 0.945 | 0.936 | 1.306 |
(0.774-1.154) | (0.687-1.276) | (0.920-1.855) | ||||||
0.578 | 0.676 | 0.135 | ||||||
Female RF- (75) | 64 (42.7) | 86 (57.3) | 12 (16.0) | 40 (53.3) | 23 (30.7) | 0.858 | 1.037 | 1.569 |
(0.606-1.215) | (0.611-1.761) | (0.816-3.018) | ||||||
0.388 | 0.892 | 0.177 | ||||||
Female ACPA+ (243) | 225 (46.3) | 261 (53.7) | 50 (20.6) | 125 (51.4) | 68 (28.0) | 0.994 | 0.911 | 1.154 |
(0.798-1.238) | (0.647-1.285) | (0.790-1.685) | ||||||
0.956 | 0.596 | 0.459 | ||||||
Female ACPA- (84) | 77 (45.8) | 91 (54.2) | 15 (17.9) | 47 (56.0) | 22 (26.2) | 0.975 | 0.832 | 1.375 |
(0.701-1.356) | (0.492-1.407) | (0.756-2.502) | ||||||
0.882 | 0.493 | 0.297 | ||||||
Male CON (105) | 99 (47.1) | 111 (52.9) | 26 (24.8) | 47 (44.8) | 32 (30.5) | |||
Male RA (121) | 116 (47.9) | 126 (52.1) | 24 (19.8) | 68 (56.2) | 29 (24.0) | 1.032 | 0.719 | 1.330 |
(0.713-1.495) | (0.399-1.296) | (0.709-2.496) | ||||||
0.867 | 0.272 | 0.374 | ||||||
Male RF+ (84) | 75 (44.6) | 93 (55.4) | 15 (17.9) | 45 (53.6) | 24 (28.6) | 0.904 | 0.913 | 1.514 |
(0.602-1.359) | (0.486-1.713) | (0.742-3.088) | ||||||
0.628 | 0.776 | 0.254 | ||||||
Male RF- (19) | 22 (57.9) | 16 (42.1) | 5 (26.3) | 12 (63.2) | 2 (10.5) | 1.542 | 0.268 | 0.922 |
(0.767-3.100) | (0.059-1.231) | (0.303-2.805) | ||||||
0.222 | 0.090 | 0.886 | ||||||
Male ACPA+ (57) | 56 (49.1) | 58 (50.9) | 12 (21.1) | 32 (56.1) | 13 (22.8) | 1.083 | 0.674 | 1.234 |
(0.686-1.709) | (0.320-1.420) | (0.568-2.681) | ||||||
0.733 | 0.300 | 0.595 | ||||||
Male ACPA- (27) | 29 (53.7) | 25 (46.3) | 5 (18.5) | 19 (70.4) | 3 (11.1) | 1.301 | 0.285 | 1.448 |
(0.714-2.369) | (0.080-1.016) | (0.498-4.211) | ||||||
0.390 | 0.053 | 0.497 | ||||||