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Table 3 Association analysis of rs7044343 with RA in the validation population

From: Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis

Characteristic ( n) Allele frequency (%) Genotype frequency (%) T vs. C CC vs. TT + TC CC + TC vs. TT
T C TT TC CC OR (95% CI) OR (95% CI) OR (95% CI)
P value P value P value
Control (456) 409 (44.8) 503 (55.2) 100 (21.9) 209 (45.8) 147 (32.2)    
RA (586) 548 (46.8) 624 (53.2) 118 (20.1) 312 (53.2) 156 (26.6) 1.080 0.763 1.114
(0.908-1.285) (0.583-0.998) (0.825-1.504)
0.385 0.048* 0.480
RF + (354) 322 (45.5) 386 (54.5) 67 (18.9) 188 (53.1) 99 (28.0) 1.026 0.816 1.203
(0.842-1.250) (0.602-1.106) (0.851-1.701)
0.799 0.190 0.295
RF- (98) 100 (51.0) 96 (49.0) 25 (25.5) 50 (51.0) 23 (23.5) 1.281 0.645 0.820
(0.941-1.745) (0.388-1.070) (0.495-1.360)
0.116 0.089 0.442
ACPA + (281) 257 (45.7) 305 (54.3) 51 (18.1) 155 (55.2) 75 (26.7) 1.036 0.765 1.267
(0.839-1.280) (0.551-1.064) (0.870-1.845)
0.741 0.111 0.217
ACPA- (92) 94 (51.1) 90 (48.9) 21 (22.8) 52 (56.5) 19 (20.7) 1.284 0.547 0.950
(0.935-1.764) (0.318-0.940) (0.556-1.622)
0.121 0.029* 0.850
Female control (363) 319 (43.9) 407 (56.1) 75 (20.7) 169 (46.6) 119 (32.8)    
Female RA (441) 413 (46.8) 469 (53.2) 87 (19.7) 239 (54.2) 115 (26.1) 1.124 0.723 1.060
(0.922-1.369) (0.533-0.982) (0.750-1.497)
0.247 0.038 0.743
Female RF+ (291) 264 (45.4) 318 (54.6) 53 (18.2) 158 (54.3) 80 (27.5) 1.059 0.777 1.169
(0.851-1.319) (0.554-1.090) (0.791-2.730)
0.607 0.144 0.433
Female RF- (75) 77 (51.3) 73 (48.7) 20 (26.7) 37 (49.3) 18 (24.0) 1.346 0.648 0.716
(0.946-1.914) (0.365-1.149) (0.404-1.268)
0.098 0.137 0.252
Female ACPA+ (234) 217 (46.4) 251 (53.6) 43 (18.4) 131 (56.0) 60 (25.6) 1.103 0.707 1.157
(0.873-1.393) (0.490-1.020) (0.762-1.755)
0.410 0.064 0.494
Female ACPA- (73) 74 (50.7) 72 (49.3) 18 (24.7) 38 (52.1) 17 (23.3) 1.311 0.622 0.796
(0.919-1.872) (0.347-1.118) (0.441-1.435)
0.135 0.112 0.448
Male CON (89) 86 (48.3) 92 (51.7) 24 (27.0) 38 (42.7) 27 (30.3)    
Male RA (102) 98 (48.0) 106 (52.0) 23 (22.5) 52 (51.0) 27 (26.5) 0.956 0.827 1.268
(0.615-1.486) (0.440-1.553) (0.656-2. 452)
0.840 0.554 0.480
Male RF+ (63) 58 (46.0) 68 (54.0) 14 (22.2) 30 (47.6) 19 (30.2) 0.827 0.992 1.292
(0.527-1.299) (0.491-2.002) (0.607-2.753)
0.410 0.981 0.506
Male RF- (22) 23 (52.3) 21 (47.7) 5 (22.7) 13 (59.1) 4 (18.2) 1.172 0.510 1.255
(0.605-2.268) (0.158-1.651) (0.417-3.777)
0.638 0.261 0.686
Male ACPA+ (47) 40 (42.6) 54 (57.4) 8 (17.0) 24 (51.1) 15 (31.9) 0.792 1.076 1.800
(0.479-1.311) (0.502-2.306) (0.737-4.397)
0.365 0.850 0.197
Male ACPA- (18) 19 (52.8) 17 (47.2) 3 (16.7) 13 (72.2) 2 (11.1) 0.376 0.287 1.846
(0.207-0.686) (0.062-1.336) (0.491-6.946)
0.001 0.112 0.364
  1. *P < 0.05 versus controls; ACPA anti-citrullinated proteins antibodies; CI confidence interval CON healthy controls; OR Odds ratio RA rheumatoid arthritis; RF rheumatoid factor.