From: Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis
Characteristic ( n) | Allele frequency (%) | Genotype frequency (%) | T vs. C | CC vs. TT + TC | CC + TC vs. TT | |||
---|---|---|---|---|---|---|---|---|
T | C | TT | TC | CC | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
P value | P value | P value | ||||||
Control (456) | 409 (44.8) | 503 (55.2) | 100 (21.9) | 209 (45.8) | 147 (32.2) | |||
RA (586) | 548 (46.8) | 624 (53.2) | 118 (20.1) | 312 (53.2) | 156 (26.6) | 1.080 | 0.763 | 1.114 |
(0.908-1.285) | (0.583-0.998) | (0.825-1.504) | ||||||
0.385 | 0.048* | 0.480 | ||||||
RF + (354) | 322 (45.5) | 386 (54.5) | 67 (18.9) | 188 (53.1) | 99 (28.0) | 1.026 | 0.816 | 1.203 |
(0.842-1.250) | (0.602-1.106) | (0.851-1.701) | ||||||
0.799 | 0.190 | 0.295 | ||||||
RF- (98) | 100 (51.0) | 96 (49.0) | 25 (25.5) | 50 (51.0) | 23 (23.5) | 1.281 | 0.645 | 0.820 |
(0.941-1.745) | (0.388-1.070) | (0.495-1.360) | ||||||
0.116 | 0.089 | 0.442 | ||||||
ACPA + (281) | 257 (45.7) | 305 (54.3) | 51 (18.1) | 155 (55.2) | 75 (26.7) | 1.036 | 0.765 | 1.267 |
(0.839-1.280) | (0.551-1.064) | (0.870-1.845) | ||||||
0.741 | 0.111 | 0.217 | ||||||
ACPA- (92) | 94 (51.1) | 90 (48.9) | 21 (22.8) | 52 (56.5) | 19 (20.7) | 1.284 | 0.547 | 0.950 |
(0.935-1.764) | (0.318-0.940) | (0.556-1.622) | ||||||
0.121 | 0.029* | 0.850 | ||||||
Female control (363) | 319 (43.9) | 407 (56.1) | 75 (20.7) | 169 (46.6) | 119 (32.8) | |||
Female RA (441) | 413 (46.8) | 469 (53.2) | 87 (19.7) | 239 (54.2) | 115 (26.1) | 1.124 | 0.723 | 1.060 |
(0.922-1.369) | (0.533-0.982) | (0.750-1.497) | ||||||
0.247 | 0.038 | 0.743 | ||||||
Female RF+ (291) | 264 (45.4) | 318 (54.6) | 53 (18.2) | 158 (54.3) | 80 (27.5) | 1.059 | 0.777 | 1.169 |
(0.851-1.319) | (0.554-1.090) | (0.791-2.730) | ||||||
0.607 | 0.144 | 0.433 | ||||||
Female RF- (75) | 77 (51.3) | 73 (48.7) | 20 (26.7) | 37 (49.3) | 18 (24.0) | 1.346 | 0.648 | 0.716 |
(0.946-1.914) | (0.365-1.149) | (0.404-1.268) | ||||||
0.098 | 0.137 | 0.252 | ||||||
Female ACPA+ (234) | 217 (46.4) | 251 (53.6) | 43 (18.4) | 131 (56.0) | 60 (25.6) | 1.103 | 0.707 | 1.157 |
(0.873-1.393) | (0.490-1.020) | (0.762-1.755) | ||||||
0.410 | 0.064 | 0.494 | ||||||
Female ACPA- (73) | 74 (50.7) | 72 (49.3) | 18 (24.7) | 38 (52.1) | 17 (23.3) | 1.311 | 0.622 | 0.796 |
(0.919-1.872) | (0.347-1.118) | (0.441-1.435) | ||||||
0.135 | 0.112 | 0.448 | ||||||
Male CON (89) | 86 (48.3) | 92 (51.7) | 24 (27.0) | 38 (42.7) | 27 (30.3) | |||
Male RA (102) | 98 (48.0) | 106 (52.0) | 23 (22.5) | 52 (51.0) | 27 (26.5) | 0.956 | 0.827 | 1.268 |
(0.615-1.486) | (0.440-1.553) | (0.656-2. 452) | ||||||
0.840 | 0.554 | 0.480 | ||||||
Male RF+ (63) | 58 (46.0) | 68 (54.0) | 14 (22.2) | 30 (47.6) | 19 (30.2) | 0.827 | 0.992 | 1.292 |
(0.527-1.299) | (0.491-2.002) | (0.607-2.753) | ||||||
0.410 | 0.981 | 0.506 | ||||||
Male RF- (22) | 23 (52.3) | 21 (47.7) | 5 (22.7) | 13 (59.1) | 4 (18.2) | 1.172 | 0.510 | 1.255 |
(0.605-2.268) | (0.158-1.651) | (0.417-3.777) | ||||||
0.638 | 0.261 | 0.686 | ||||||
Male ACPA+ (47) | 40 (42.6) | 54 (57.4) | 8 (17.0) | 24 (51.1) | 15 (31.9) | 0.792 | 1.076 | 1.800 |
(0.479-1.311) | (0.502-2.306) | (0.737-4.397) | ||||||
0.365 | 0.850 | 0.197 | ||||||
Male ACPA- (18) | 19 (52.8) | 17 (47.2) | 3 (16.7) | 13 (72.2) | 2 (11.1) | 0.376 | 0.287 | 1.846 |
(0.207-0.686) | (0.062-1.336) | (0.491-6.946) | ||||||
0.001 | 0.112 | 0.364 |