Table 4 Association analysis of rs7044343 with RA in the replication population
From: Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis
Characteristic ( n) | Allele frequency (%) | Genotype frequency (%) | T vs. C | CC vs. TT + TC | CC + TC vs. TT | |||
|---|---|---|---|---|---|---|---|---|
T | C | TT | TC | CC | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
P-value | P.-value | P-value | ||||||
Control (701) | 631 (45.0) | 771 (55.0) | 154 (22.0) | 323 (46.1) | 224 (32.0) | |||
RA (666) | 632 (47.4) | 700 (52.6) | 144 (21.6) | 344 (51.7) | 178 (26.7) | 1.103 | 0.777 | 1.021 |
(0.949-1.282) | (0.615-0.981) | (0.789-1.320) | ||||||
0.201 | 0.034* | 0.877 | ||||||
RF + (325) | 300 (46.2) | 350 (53.8) | 73 (22.5) | 154 (47.4) | 98 (30.2) | 1.047 | 0.919 | 0.972 |
(0.869-1.262) | (0.691-1.223) | (0.709-1.333) | ||||||
0.627 | 0.563 | 0.860 | ||||||
RF-(62) | 54 (43.5) | 70 (56.5) | 10 (16.1) | 34 (54.8) | 18 (29.0) | 0.943 | 0.871 | 1.464 |
(0.651-1.365) | (0.492-1.542) | (0.727-2.948) | ||||||
0.754 | 0.636 | 0.286 | ||||||
ACPA + (224) | 192 (42.9) | 256 (57.1) | 39 (17.4) | 114 (50.9) | 71 (31.7) | 0.916 | 0.988 | 1.335 |
(0.739-1.136) | (0.715-1.365) | (0.905-1.970) | ||||||
0.425 | 0.943 | 0.2145 | ||||||
ACPA-(101) | 103 (51.0) | 99 (49.0) | 23 (22.8) | 57 (56.4) | 21 (20.8) | 1.271 | 0.559 | 0.955 |
(0.946-1.708) | (0.337-0.927) | (0.580-1.571) | ||||||
0.111 | 0.024* | 0.856 | ||||||
Female Control (519) | 474 (45.7) | 564 (54.3) | 114 (22.0) | 246 (47.4) | 159 (30.6) | |||
Female RA (458) | 410 (44.8) | 506 (55.2) | 92 (20.1) | 226 (49.3) | 140 (30.6) | 1.040 | 0.997 | 1.120 |
(0.869-1.246) | (0.759-1.309) | (0.822-1.525) | ||||||
0.668 | 0.982 | 0.473 | ||||||
Female RF+ (256) | 237 (46.3) | 275 (53.7) | 56 (21.9) | 125 (48.8) | 75 (29.3) | 1.025 | 0.938 | 1.005 |
(0.829-1.268) | (0.676-1.302) | (0.700-1.444) | ||||||
0.817 | 0.703 | 0.977 | ||||||
Female RF- (53) | 46 (43.4) | 60 (56.6) | 8 (15.1) | 30 (56.6) | 15 (28.3) | 0.912 | 0.894 | 1.583 |
(0.610-1.365) | (0.478-1.672) | (0.726-3.455) | ||||||
0.655 | 0.725 | 0.248 | ||||||
Female ACPA+ (158) | 133 (42.1) | 183 (57.9) | 27 (17.1) | 79 (50.0) | 52 (32.9) | 0.865 | 1.111 | 1.366 |
(0.670-1.115) | (0.759-1.625) | (0.859-2.171) | ||||||
0.263 | 0.589 | 0.187 | ||||||
Female ACPA- (76) | 72 (47.4) | 80 (52.6) | 14 (18.4) | 44 (57.9) | 18 (23.7) | 1.071 | 0.703 | 1.247 |
(0.761-1.506) | (0.401-1.231) | (0.673-2.308) | ||||||
0.694 | 0.217 | 0.483 | ||||||
Male CON (130) | 125 (48.1) | 135 (51.9) | 30 (23.1) | 65 (50.0) | 35 (26.9) | |||
Male RA (95) | 75 (39.5) | 115 (60.5) | 16 (16.8) | 43 (45.3) | 36 (37.9) | 0.704 | 1.656 | 1.481 |
(0.482-1.029) | (0.939-2.921) | (0.754-2. 908) | ||||||
0.070 | 0.081 | 0.254 | ||||||
Male RF+ (54) | 42 (38.9) | 66 (61.1) | 10 (18.5) | 22 (40.7) | 22 (40.7) | 0.687 | 1.866 | 1.320 |
(0.435-1.085) | (0.958-3.636) | (0.594-2.934) | ||||||
0.107 | 0.067 | 0.496 | ||||||
Male RF- (9) | 8 (44.4) | 10 (55.6) | 2 (22.2) | 4 (44.4) | 3 (33.3) | 0.864 | 1.357 | 1.050 |
(0.330-2.259) | (0.322-5.723) | (0.207-5.325) | ||||||
0.765 | 0.677 | 0.953 | ||||||
Male ACPA+ (44) | 29 (33.0) | 59 (67.0) | 4 (9.1) | 21 (47.7) | 19 (43.2) | 0.531 | 2.063 | 3.000 |
(0.320-0.881) | (1.013-4.202) | (0. 993–9.065) | ||||||
0.014 | 0.046 | 0.052 | ||||||
Male ACPA- (11) | 13 (59.1) | 9 (40.9) | 5 (45.5) | 3 (27.3) | 3 (27.3) | 1.560 | 1.018 | 0.360 |
(0.644-3.776) | (0.255-4.055) | (0.103-1.263) | ||||||
0.321 | 0.980 | 0.111 | ||||||