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Table 4 Association analysis of rs7044343 with RA in the replication population

From: Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis

Characteristic ( n) Allele frequency (%) Genotype frequency (%) T vs. C CC vs. TT + TC CC + TC vs. TT
T C TT TC CC OR (95% CI) OR (95% CI) OR (95% CI)
P-value P.-value P-value
Control (701) 631 (45.0) 771 (55.0) 154 (22.0) 323 (46.1) 224 (32.0)    
RA (666) 632 (47.4) 700 (52.6) 144 (21.6) 344 (51.7) 178 (26.7) 1.103 0.777 1.021
(0.949-1.282) (0.615-0.981) (0.789-1.320)
0.201 0.034* 0.877
RF + (325) 300 (46.2) 350 (53.8) 73 (22.5) 154 (47.4) 98 (30.2) 1.047 0.919 0.972
(0.869-1.262) (0.691-1.223) (0.709-1.333)
0.627 0.563 0.860
RF-(62) 54 (43.5) 70 (56.5) 10 (16.1) 34 (54.8) 18 (29.0) 0.943 0.871 1.464
(0.651-1.365) (0.492-1.542) (0.727-2.948)
0.754 0.636 0.286
ACPA + (224) 192 (42.9) 256 (57.1) 39 (17.4) 114 (50.9) 71 (31.7) 0.916 0.988 1.335
(0.739-1.136) (0.715-1.365) (0.905-1.970)
0.425 0.943 0.2145
ACPA-(101) 103 (51.0) 99 (49.0) 23 (22.8) 57 (56.4) 21 (20.8) 1.271 0.559 0.955
(0.946-1.708) (0.337-0.927) (0.580-1.571)
0.111 0.024* 0.856
Female Control (519) 474 (45.7) 564 (54.3) 114 (22.0) 246 (47.4) 159 (30.6)    
Female RA (458) 410 (44.8) 506 (55.2) 92 (20.1) 226 (49.3) 140 (30.6) 1.040 0.997 1.120
(0.869-1.246) (0.759-1.309) (0.822-1.525)
0.668 0.982 0.473
Female RF+ (256) 237 (46.3) 275 (53.7) 56 (21.9) 125 (48.8) 75 (29.3) 1.025 0.938 1.005
(0.829-1.268) (0.676-1.302) (0.700-1.444)
0.817 0.703 0.977
Female RF- (53) 46 (43.4) 60 (56.6) 8 (15.1) 30 (56.6) 15 (28.3) 0.912 0.894 1.583
(0.610-1.365) (0.478-1.672) (0.726-3.455)
0.655 0.725 0.248
Female ACPA+ (158) 133 (42.1) 183 (57.9) 27 (17.1) 79 (50.0) 52 (32.9) 0.865 1.111 1.366
(0.670-1.115) (0.759-1.625) (0.859-2.171)
0.263 0.589 0.187
Female ACPA- (76) 72 (47.4) 80 (52.6) 14 (18.4) 44 (57.9) 18 (23.7) 1.071 0.703 1.247
(0.761-1.506) (0.401-1.231) (0.673-2.308)
0.694 0.217 0.483
Male CON (130) 125 (48.1) 135 (51.9) 30 (23.1) 65 (50.0) 35 (26.9)    
Male RA (95) 75 (39.5) 115 (60.5) 16 (16.8) 43 (45.3) 36 (37.9) 0.704 1.656 1.481
(0.482-1.029) (0.939-2.921) (0.754-2. 908)
0.070 0.081 0.254
Male RF+ (54) 42 (38.9) 66 (61.1) 10 (18.5) 22 (40.7) 22 (40.7) 0.687 1.866 1.320
(0.435-1.085) (0.958-3.636) (0.594-2.934)
0.107 0.067 0.496
Male RF- (9) 8 (44.4) 10 (55.6) 2 (22.2) 4 (44.4) 3 (33.3) 0.864 1.357 1.050
(0.330-2.259) (0.322-5.723) (0.207-5.325)
0.765 0.677 0.953
Male ACPA+ (44) 29 (33.0) 59 (67.0) 4 (9.1) 21 (47.7) 19 (43.2) 0.531 2.063 3.000
(0.320-0.881) (1.013-4.202) (0. 993–9.065)
0.014 0.046 0.052
Male ACPA- (11) 13 (59.1) 9 (40.9) 5 (45.5) 3 (27.3) 3 (27.3) 1.560 1.018 0.360
(0.644-3.776) (0.255-4.055) (0.103-1.263)
0.321 0.980 0.111
  1. *P < 0.05 vs controls; RA rheumatoid arthritis; CON healthy controls; RF rheumatoid factor; ACPA anti-citrullinated proteins antibodies; OR Odds ratio; CI confidence interval.