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Table 2 Overview of imaging observations and explant activity a

From: Synovial explant inflammatory mediator production corresponds to rheumatoid arthritis imaging hallmarks: a cross-sectional study

Variable

Observations No. patients (No. synovectomies)

Median [IQR] (min;max)

Imaging

  

Focal RAMRIS BME score, 0-3

  

 Wrist

12 (34)

1.8 [0.8 to 3.0] (0.0; 3.0)

 MCP

4 (4)

2.0 [1.3 to 2.8] (0.0; 3.0)

 PIP

3 (4)

2.0 [1.0 to 2.5] (1.0; 2.5)

 Total

19 (42)

1.5 [1.0 to 2.8] (0.0; 3.0)

CFmax, 0-1

  

 Wrist

17 (48)

0.08 [0.02 to 0.23] (0.0; 0.86)

 MCP

4(4)

0.12 [0.05 to 0.34] (0.03; 0.52)

 PIP

3(4)

0.06 [0.03 to 0.07](0.0: 0.08)

 Total

24 (56)

0.08 [0.01 to 0.21] (0.0; 0.86)

Explant mediator production, pg/mL

  

MCP-1

  

 Wrist

17 (48)

4,848 [1,138 to 15,000] (240.5; 46,450)

 MCP

6 (6)

2,444 [840 to 11,175] (240.5; 31,336)

 PIP

3 (4)

2,082 [986 to 2,707] (348; 3,053)

 Total

25 (58)

3,865 [1,138 to 12,915] (240.5; 46,450)

IL-6

  

 Wrist

17 (48)

8,465 [1,321 to 39469] (72.5; 266,857)

 MCP

6 (6)

4,969 [391 to 37,496] (72.5; 534,340)

 PIP

3 (4)

11,901 [1,761 to 29,205] (732; 37,400)

 Total

25 (58)

8,031 [1,156 to 37,400] (72.5; 534,340)

IL-8

  

 Wrist

17 (48)

21,129 [5,649 to 96,401] (26,5; 137,001)

 MCP

6 (6)

21,132 [5,405 to 48,883] (4,571; 137,001)

 PIP

3 (4)

20,730 [6,388 to 50,750] (2,017; 70,800)

 Total

25 (58)

21,129 [5,503 to 89,643] (26.5; 137,001)

MIP-1β

  

 Wrist

17 (48)

1,812 [530 to 6,828] (366.5; 28,420)

 MCP

6 (6)

1,078 [577 to 2,786] (366.5; 19,120)

 PIP

3 (4)

555 [354 to 1,724] (366.5; 2,705)

 Total

25 (58)

1,331 [502 to 5,196] (366.5; 28,420)

  1. Depicting an overview of the imaging activity and synovial explant mediator production. Avr. = average, CFmax = colour fraction measured in the systole, IL-6 = Interleukin 6, IL-8 = Interleukin 8, IQR = Interquartile range (3rd quartile – 1st quartile), Max. = maximum, MCP = Metacarpo-phalangeal joint, MCP-1 = macrophage chemoattractant protein 1, Min. = minimum, MIP-1b = Macrophage inflammatory protein 1 beta, no. = number , PIP = Proximal interphalangeal joint, RAMRIS BME Score = Rheumatoid Arthritis Magnetic Ressonance Bone Marrow Oedema Score.
  2. 1 Mean ± Standard deviation.