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Table 2 Overview of imaging observations and explant activity a

From: Synovial explant inflammatory mediator production corresponds to rheumatoid arthritis imaging hallmarks: a cross-sectional study

Variable Observations No. patients (No. synovectomies) Median [IQR] (min;max)
Imaging   
Focal RAMRIS BME score, 0-3   
 Wrist 12 (34) 1.8 [0.8 to 3.0] (0.0; 3.0)
 MCP 4 (4) 2.0 [1.3 to 2.8] (0.0; 3.0)
 PIP 3 (4) 2.0 [1.0 to 2.5] (1.0; 2.5)
 Total 19 (42) 1.5 [1.0 to 2.8] (0.0; 3.0)
CFmax, 0-1   
 Wrist 17 (48) 0.08 [0.02 to 0.23] (0.0; 0.86)
 MCP 4(4) 0.12 [0.05 to 0.34] (0.03; 0.52)
 PIP 3(4) 0.06 [0.03 to 0.07](0.0: 0.08)
 Total 24 (56) 0.08 [0.01 to 0.21] (0.0; 0.86)
Explant mediator production, pg/mL   
MCP-1   
 Wrist 17 (48) 4,848 [1,138 to 15,000] (240.5; 46,450)
 MCP 6 (6) 2,444 [840 to 11,175] (240.5; 31,336)
 PIP 3 (4) 2,082 [986 to 2,707] (348; 3,053)
 Total 25 (58) 3,865 [1,138 to 12,915] (240.5; 46,450)
IL-6   
 Wrist 17 (48) 8,465 [1,321 to 39469] (72.5; 266,857)
 MCP 6 (6) 4,969 [391 to 37,496] (72.5; 534,340)
 PIP 3 (4) 11,901 [1,761 to 29,205] (732; 37,400)
 Total 25 (58) 8,031 [1,156 to 37,400] (72.5; 534,340)
IL-8   
 Wrist 17 (48) 21,129 [5,649 to 96,401] (26,5; 137,001)
 MCP 6 (6) 21,132 [5,405 to 48,883] (4,571; 137,001)
 PIP 3 (4) 20,730 [6,388 to 50,750] (2,017; 70,800)
 Total 25 (58) 21,129 [5,503 to 89,643] (26.5; 137,001)
MIP-1β   
 Wrist 17 (48) 1,812 [530 to 6,828] (366.5; 28,420)
 MCP 6 (6) 1,078 [577 to 2,786] (366.5; 19,120)
 PIP 3 (4) 555 [354 to 1,724] (366.5; 2,705)
 Total 25 (58) 1,331 [502 to 5,196] (366.5; 28,420)
  1. Depicting an overview of the imaging activity and synovial explant mediator production. Avr. = average, CFmax = colour fraction measured in the systole, IL-6 = Interleukin 6, IL-8 = Interleukin 8, IQR = Interquartile range (3rd quartile – 1st quartile), Max. = maximum, MCP = Metacarpo-phalangeal joint, MCP-1 = macrophage chemoattractant protein 1, Min. = minimum, MIP-1b = Macrophage inflammatory protein 1 beta, no. = number , PIP = Proximal interphalangeal joint, RAMRIS BME Score = Rheumatoid Arthritis Magnetic Ressonance Bone Marrow Oedema Score.
  2. 1 Mean ± Standard deviation.