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Table 3 Statistical associations with rheumatoid arthritis explant mediator release at 72 hours vs. at time of imaging a

From: Synovial explant inflammatory mediator production corresponds to rheumatoid arthritis imaging hallmarks: a cross-sectional study

Imaging/mediator CF max RAMRIS synovitis RAMRIS BME RAMRIS erosion
  P-value (approximate ρ) P-value (approximate ρ) P-value (approximate ρ) P-value (approximate ρ)
MCP-1 0.009 (0.41) 0.17 (0.48) 0.01 (0.42) 0.03 (0.31)
IL-6 0.23 (0.22) 0.04 (0.50) 0.04 (0.25) 0.03 (0.35)
IL-8 0.09 (0.27) 0.08 (0.58) 0.16 (0.27) 0.07 (0.43)
MIP-1β 0.02 (0.38) 0.02 (0.63) 0.95 (0.35) 0.62 (0.30)
  1. aCFmax, Maximal systolic colour fraction; BME, Bone marrow oedema; IL, Interleukin; MCP-1, Monocyte chemoattractant protein 1; MIP-1, Macrophage inflammatory protein 1β; RAMRIS, Rheumatoid arthritis magnetic resonance imaging score.
  2. A mixed model has been used for the statistical analysis: P < 0.05 was considered significant. In the reduced model, covariates were excluded if P > 0.10. This table contains the data from the reduced models. The full models including stepwise covariate elimination steps and model optimization transformation can be found in the supplementary files.
  3. The pre-specified covariates included in the statistical model: Joint Synovectomized = Wrist, MCP or PIP; Synovectomy position = Ulnar, central, radial, or mixed for pooled synovectomy positions; Side = left or right;
  4. Approx. rho = approximated Spearman’s rho; RAMRIS BME = RAMRIS bone marrow edema component; RAMRIS Erosion = RAMRIS erosion score component; RAMRIS synovitis = RAMRIS synovitis score component; IL-6 = Interleukin 6; IL-8 = Interleukin 8, MCP-1 = Monocyte chemoattractant protein 1; MIP-1b = Macrophage Inflammatory Protein 1 beta.