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Figure 1 | Arthritis Research & Therapy

Figure 1

From: A genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis

Figure 1

Schematic presentation of the OPG/RANK/RANKL/TRAF6 pathway in osteoclasts. The RANK signaling cascade is initiated upon the binding of RANKL to the extracellular domain of RANK which panes the signal along to TRAF6. The activation of TRAF6 initiates pathways leading to the activation of several transcription factors (among which NFκβ and MAP kinase mediators), which contribute to osteoclast differentiation, activation and survival. OPG is able to prevent the interaction between RANKL and RANK.

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