Network analysis of juvenile idiopathic arthritis (JIA)-associated genes. (A) A collated list of 348 JIA-associated genes was used to derive an interaction network inferred from the BioGRID model of the human interactome (3.2.99); red = JIA-associated gene, blue = inferred interaction (Figure 1B). (B) Minimal essential network of top 10% of the genes from the JIA interactome, ranked by connectivity and bottleneck, colours represent clusters of related genes calculated by spectral partition clustering  (Figure 1Bi). (C)
Biological pathways associated with minimal essential network (MEN) clusters (colour of cluster relates to Figure 2B), false discovery rate (FDR) P-value of hypergeometric test (P ≤0.05) (Figure 1Bi). MHC Major histocompatibility complex, FGF Fibroblast growth factor, PDGF
Platelet-derived growth factor IGF-1 Insulin-like growth factor 1, TGF beta Transforming growth factor beta, IL-2
Interleukin 2, IL-8 Interleukin 8 PI3K
Phosphoinositide 3-kinase, TNF Tumour necrosis factor, CXCR1 chemokine (C-X-C motif) receptor 1, CXCR2
chemokine (C-X-C motif) receptor 2.