Figure 3

Changes in connectivity of juvenile idiopathic arthritis (JIA)-associated genes. The Disease Association Protein-Protein Link Evaluator (Dapple) algorithm was used to generate an inferred interactome network from the 348 JIA-associated genes, an iterative process was then used to generate random networks and significant changes in seed gene connectivity were calculated. The JIA-associated seed genes are shown coloured by significance of deviation of observed network connectivity from expected (red = highly significant to green = not significant) (Figure 1Bii).