Table 2 Disease-specific characteristics
Characteristics | Number | SSc-overlap (n = 25) | Number | SSc (n = 397) | Number | PM (n = 40) | P value |
|---|---|---|---|---|---|---|---|
Scleroderma features | |||||||
Raynaud phenomena | 25 | 21 (84%) | 397 | 379 (96%) | 40 | 13 (33%) | <0.001 |
Digital ulcers | 25 | 6 (24%) | 397 | 164 (41%) | 40 | 3 (8%) | <0.001 |
Pitting scars | - | 397 | 160 (40%) | NA | NA | ||
Rodnan skin score (median) | 15 | 6 (5–11) | 372 | 7 (4–12) | NA | NS | |
Renal crisis | 25 | 1 (4%) | 397 | 17 (4%) | NA | NS | |
Myositis features | |||||||
Serum CK elevation‡ | 25 | 24 (96%) | 397 | 48 (12%) | 40 | 34 (85%) | <0.001 |
Proximal muscle weakness | 25 | 25 (100%) | 397 | 21 (5%) | 40 | 37 (93%) | <0.001 |
Myopathic EMG findings | 25 | 22 (88%) | NA | 29 | 24 (83%) | NS | |
Mechanic hands | NA | NA | 40 | 7 (18%) | NS | ||
Internal complications | |||||||
Arthritis | 25 | 5 (20%) | 397 | 46 (12%) | 40 | 7 (18%) | NS |
Interstitial lung disease | |||||||
HRCT fibrosis | 18 | 15 (83%) | 346 | 170 (49%) | 19 | 10 (53%) | 0.044 |
TLC ≤70% of predicted | 21 | 4 (19%) | 364 | 68 (19%) | 23 | 9 (39%) | NS |
TLCO ≤70% of predicted | 17 | 17 (100%) | 347 | 260 (75%) | 20 | 13 (65%) | 0.001 |
Diastolic dysfunction by cardiac ultrasound | 19 | 7 (37%) | 352 | 146 (42%) | 19 | 4 (21%) | NS |
PH suspicion by cardiac ultrasound | 20 | 3 (15%) | 352 | 89 (25%) | 19 | 2 (11%) | 0.042 |
PH by cardiac catherization | 5 | 0 | 182 | 57 (31%) | 2 | 1 (50%) | 0.002 |
Myocarditis | 25 | 1 (4%) | NA | 40 | 0 | NS | |
Malignancy | 25 | 2 (8%) | NA | 40 | 5 (13%) | NS |