Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans

Table 3 Comparison of the clinical characteristics according to the genotype and haplotype of NR1H3 gene in SLE

Characteristics	-1830 T > C			-1003G > A			-115G > A
	TT	CT,CC	P	GG	GA,AA	P	GG	GA,AA	P
	n = 238 (79.3%)	n = 62 (20.7%)	value	n = 250 (83.3%)	n = 50 (6.7%)	value	n = 235 (78.3%)	n = 65 (21.7%)	value
Oral ulcer^a	122 (51.3%)	26 (41.9%)	0.191	130 (52.0%)	18 (36.0%)	0.039	124 (52.8%)	24 (36.9%)	0.024
Arthritis^a	151 (63.4%)	51 (82.3%)	0.005	160 (64.0%)	42 (84.0%)	0.006	146 (62.1%)	56 (86.2%)	<0.001
Anti-ds DNA^a	156 (65.5%)	47 (75.8%)	0.124	163 (65.2%)	40 (80.0%)	0.041	153 (65.1%)	50 (76.9%)	0.071
CNS involvement^a	19 (8.0%)	3 (4.8%)	0.295	22 (8.8%)	0 (0.0%)	0.015	20 (8.5%)	2 (3.1%)	0.106
Triglyceride^b	97.8 ± 64.1	112.8 ± 67.1	0.108	95.6 ± 61.5	126.9 ± 74.9	0.007	95.3 ± 62.1	120.9 ± 71.2	0.011
Characteristics	HT1 [TTGG]			HT2 [CTGG]			HT3 [TCGG]
	+/+	+/-, -/-	P	+/+	+/-, -/-	P	+/+, +/-	-/-	P
	n = 63 (41.7%)	n = 88 (58.3%)	value	n = 24 (15.9%)	n = 127 (84.1%)	value	n = 30 (19.8%)	n = 121 (80.1%)	value
Arthritis^a	62 (56.9%)	140 (73.3%)	0.004	9 (56.3%)	193 (68.0%)	0.331	29 (90.6%)	173 (64.6%)	0.003
Leukopenia^a	61 (56.0%)	112 (58.6%)	0.652	11 (68.8%)	162 (57.0%)	0.356	20 (62.5%)	153 (57.1%)	0.558
Lymphopenia^a	100 (91.7%)	172 (90.1%)	0.628	12 (75.0%)	260 (91.5%)	0.027	30 (93.8%)	242 (90.3%)	0.526

^aThis value is presented as the number of patients positive for the feature or antibody. ^bThis value was presented as the means ± SD. Leukopenia is defined as a leukocyte count that is less than 4 × 10³ cells/μL. Lymphopenia is defined as the lymphocyte count that is less than 1 × 10³ cells/μL. Logistic regression analysis was applied to control for age and sex as covariables. No association with SLE phenotypes was observed when the other SNPs were evaluated. No association with SLE phenotypes was observed when the other haplotypes were evaluated. HT, haplotype; SLE, systemic lupus erythematosus; SNP, single nucleotide polymorphism.

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