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Table 3 Comparison of the clinical characteristics according to the genotype and haplotype of NR1H3 gene in SLE

From: Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans

Characteristics -1830 T > C -1003G > A -115G > A
TT CT,CC P GG GA,AA P GG GA,AA P
n = 238 (79.3%) n = 62 (20.7%) value n = 250 (83.3%) n = 50 (6.7%) value n = 235 (78.3%) n = 65 (21.7%) value
Oral ulcera 122 (51.3%) 26 (41.9%) 0.191 130 (52.0%) 18 (36.0%) 0.039 124 (52.8%) 24 (36.9%) 0.024
Arthritisa 151 (63.4%) 51 (82.3%) 0.005 160 (64.0%) 42 (84.0%) 0.006 146 (62.1%) 56 (86.2%) <0.001
Anti-ds DNAa 156 (65.5%) 47 (75.8%) 0.124 163 (65.2%) 40 (80.0%) 0.041 153 (65.1%) 50 (76.9%) 0.071
CNS involvementa 19 (8.0%) 3 (4.8%) 0.295 22 (8.8%) 0 (0.0%) 0.015 20 (8.5%) 2 (3.1%) 0.106
Triglycerideb 97.8 ± 64.1 112.8 ± 67.1 0.108 95.6 ± 61.5 126.9 ± 74.9 0.007 95.3 ± 62.1 120.9 ± 71.2 0.011
Characteristics HT1 [TTGG] HT2 [CTGG] HT3 [TCGG]
  +/+ +/-, -/- P +/+ +/-, -/- P +/+, +/- -/- P
  n = 63 (41.7%) n = 88 (58.3%) value n = 24 (15.9%) n = 127 (84.1%) value n = 30 (19.8%) n = 121 (80.1%) value
Arthritisa 62 (56.9%) 140 (73.3%) 0.004 9 (56.3%) 193 (68.0%) 0.331 29 (90.6%) 173 (64.6%) 0.003
Leukopeniaa 61 (56.0%) 112 (58.6%) 0.652 11 (68.8%) 162 (57.0%) 0.356 20 (62.5%) 153 (57.1%) 0.558
Lymphopeniaa 100 (91.7%) 172 (90.1%) 0.628 12 (75.0%) 260 (91.5%) 0.027 30 (93.8%) 242 (90.3%) 0.526
  1. aThis value is presented as the number of patients positive for the feature or antibody. bThis value was presented as the means ± SD. Leukopenia is defined as a leukocyte count that is less than 4 × 103 cells/μL. Lymphopenia is defined as the lymphocyte count that is less than 1 × 103 cells/μL. Logistic regression analysis was applied to control for age and sex as covariables. No association with SLE phenotypes was observed when the other SNPs were evaluated. No association with SLE phenotypes was observed when the other haplotypes were evaluated. HT, haplotype; SLE, systemic lupus erythematosus; SNP, single nucleotide polymorphism.