|
Characteristics
|
-1830 T > C
|
-1003G > A
|
-115G > A
|
|---|
|
TT
|
CT,CC
|
P
|
GG
|
GA,AA
|
P
|
GG
|
GA,AA
|
P
|
|---|
|
n = 238 (79.3%)
|
n = 62 (20.7%)
|
value
|
n = 250 (83.3%)
|
n = 50 (6.7%)
|
value
|
n = 235 (78.3%)
|
n = 65 (21.7%)
|
value
|
|---|
|
Oral ulcera
|
122 (51.3%)
|
26 (41.9%)
|
0.191
|
130 (52.0%)
|
18 (36.0%)
|
0.039
|
124 (52.8%)
|
24 (36.9%)
|
0.024
|
|
Arthritisa
|
151 (63.4%)
|
51 (82.3%)
|
0.005
|
160 (64.0%)
|
42 (84.0%)
|
0.006
|
146 (62.1%)
|
56 (86.2%)
|
<0.001
|
|
Anti-ds DNAa
|
156 (65.5%)
|
47 (75.8%)
|
0.124
|
163 (65.2%)
|
40 (80.0%)
|
0.041
|
153 (65.1%)
|
50 (76.9%)
|
0.071
|
|
CNS involvementa
|
19 (8.0%)
|
3 (4.8%)
|
0.295
|
22 (8.8%)
|
0 (0.0%)
|
0.015
|
20 (8.5%)
|
2 (3.1%)
|
0.106
|
|
Triglycerideb
|
97.8 ± 64.1
|
112.8 ± 67.1
|
0.108
|
95.6 ± 61.5
|
126.9 ± 74.9
|
0.007
|
95.3 ± 62.1
|
120.9 ± 71.2
|
0.011
|
|
Characteristics
|
HT1 [TTGG]
|
HT2 [CTGG]
|
HT3 [TCGG]
|
| |
+/+
|
+/-, -/-
|
P
|
+/+
|
+/-, -/-
|
P
|
+/+, +/-
|
-/-
|
P
|
| |
n = 63 (41.7%)
|
n = 88 (58.3%)
|
value
|
n = 24 (15.9%)
|
n = 127 (84.1%)
|
value
|
n = 30 (19.8%)
|
n = 121 (80.1%)
|
value
|
|
Arthritisa
|
62 (56.9%)
|
140 (73.3%)
|
0.004
|
9 (56.3%)
|
193 (68.0%)
|
0.331
|
29 (90.6%)
|
173 (64.6%)
|
0.003
|
|
Leukopeniaa
|
61 (56.0%)
|
112 (58.6%)
|
0.652
|
11 (68.8%)
|
162 (57.0%)
|
0.356
|
20 (62.5%)
|
153 (57.1%)
|
0.558
|
|
Lymphopeniaa
|
100 (91.7%)
|
172 (90.1%)
|
0.628
|
12 (75.0%)
|
260 (91.5%)
|
0.027
|
30 (93.8%)
|
242 (90.3%)
|
0.526
|
-
aThis value is presented as the number of patients positive for the feature or antibody. bThis value was presented as the means ± SD. Leukopenia is defined as a leukocyte count that is less than 4 × 103 cells/μL. Lymphopenia is defined as the lymphocyte count that is less than 1 × 103 cells/μL. Logistic regression analysis was applied to control for age and sex as covariables. No association with SLE phenotypes was observed when the other SNPs were evaluated. No association with SLE phenotypes was observed when the other haplotypes were evaluated. HT, haplotype; SLE, systemic lupus erythematosus; SNP, single nucleotide polymorphism.
