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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Resequencing the susceptibility gene, ITGAM, identifies two functionally deleterious rare variants in systemic lupus erythematosus cases

Figure 5

Phagocytosis of sRBC iC3b by CR3-expressing COS-7cells as measured with percentage phagocytosis. Percentage phagocytosis, mean percentage phagocytosis/COS-7 cell. Both rare variants F941V and G1145S significantly impair phagocytosis (P = 0.006 and 0.0232, respectively). No significant difference was observed between WT and either common polymorphism M441T (P = 0.70) and A858V (P = 0.47).

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Arthritis Research & Therapy

ISSN: 1478-6362

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