B cell subsets and dysfunction of regulatory B cells in IgG4-related diseases and primary Sjögren’s syndrome: the similarities and differences

Table 2 B cell phenotypes in IgG4-RD, pSS and healthy controls

	Healthy controls	IgG4-RD	pSS	IgG4-related disease versus HC	pSS versus HC	IgG4-RD versus pSS
	Healthy controls	IgG4-RD	pSS	P-value	P-value	P-value
CD19+ (%)¹	4.41 ± 1.75	6.43 ± 2.73	8.97 ± 4.40	0.001	<0.001	0.009
CD19 + CD24 + CD38- (%)²	14.01 ± 10.39	22.71 ± 12.81	15.79 ± 10.58	0.002	0.541	0.009
CD19 + CD24intCD38int (%)²	53.70 ± 15.12	36.68 ± 14.27	49.75 ± 11.59	<0.001	0.150	<0.001
CD19 + CD24hiCD38hi (%)²	3.98 ± 2.70	2.17 ± 3.96	12.55 ± 5.15	<0.001	<0.001	<0.001
CD19 + CD24-CD38hi (%)²	2.16 ± 1.65	6.99 ± 6.24	2.39 ± 2.64	<0.001	0.868	<0.001
CD19 + CD40+ (%)²	87.08 ± 11.27	44.35 ± 21.79	69.48 ± 20.33	<0.001	<0.001	<0.001
CD19 + BAFF-R + (%)²	94.13 ± 3.50	76.63 ± 20.85	88.96 ± 8.90	0.001	0.005	0.066
CD19 + CD80+ (%)²	17.54 ± 7.41	43.27 ± 8.64	23.69 ± 14.24	<0.001	0.327	0.037
CD19 + CD86+ (%)²	19.56 ± 7.70	47.18 ± 14.23	27.45 ± 12.17	0.002	0.325	0.041

Values are shown as mean ± SD. ¹Percentages of CD19+ cells in total lymphocytes. ²Percentages of B cell subsets in CD19+ cells. IgG4-RD, IgG4-related disease; pSS, primary Sjögren’s syndrome.

ISSN: 1478-6362