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Table 1 Common multipotential stromal cell genes

From: Intrinsic multipotential mesenchymal stromal cell activity in gelatinous Heberden’s nodes in osteoarthritis at clinical presentation

  

Fold changing in expression between:

Gene

HN/FB

SF/FB

ICBM/FB

ACVR2A

Activin A receptor, type IB

2.8

3.5

7.0

ANGPT1

Angiopoietin 1

5.3

4.6

4.9

BAMBI

Bone morphagenietic protein and activin membrane-bound inhibitor homolog

18.2

36.8

10.2

CDH11

Cadherin 11

11.4

8.8

9.0

COL1A1

Collagen, type I, alpha 1

15.3

4.3

6.0

COL1A2

Collagen, type I, alpha 2

20.2

20.8

9.9

CXCL12

Chemokine ligand 12

3.1

5.4

1.9

EPHB4

Ephrin receptor B4

5.5

2.3

2.6

FZD1

Frizzled family receptor 1

4.7

11.5

4.6

GDF5 a

Growth differentiation factor 5

73.5

4.04

25.5

GJA1

Gap junction protein, alpha 1

8.2

14.7

10.2

HAPLN1 a

Hyaluronan and proteoglycan link protein 1

397.3

258.5

691.3

IGFBP3

Insulin-like growth factor-binding protein 3

59.5

107.8

5.1

MYH9 a

Myosin heavy chain 9

6.0

6.0

6.8

PAPSS2

3′-phosphoadenosine 5′-phosphosulfate synthase 2

2.8

5.1

2.7

RUNX1

Runt-related transcription factor 1

3.0

59.0

1.9

SFRP4

Secreted frizzled-related protein 4

171.2

908.9

4.8

SORT1

Sortilin 1

4.4

8.9

11.1

SPARC

Secreted protein, acidic, cysteine-rich

7.0

7.0

7.1

VEGFC

Vascular endothelial growth factor C

3.1

10.2

1.6

  1. Relative fold change in expression compared with fibroblasts (FBs) (P ≤0.05, Mann-Whitney U). aNewly identified genes. HN, Heberden’s node; ICBM, normal iliac crest bone marrow; SF, synovial fluid.