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Table 2 Tissue-specific multipotential stromal cell genes

From: Intrinsic multipotential mesenchymal stromal cell activity in gelatinous Heberden’s nodes in osteoarthritis at clinical presentation

  

Fold changing in expression between:

Gene

HN/ICBM

SF/ICBM

HN/SF

ACAN

Aggrecan

12.5

15.6

0.8

ALPL

Alkaline phosphatase

4.8

6.4

0.8

BMP2

Bone morphogenetic protein 2

3.1

20.8

0.1

BMP4

Bone morphogenetic protein 4

3.2

5.6

0.6

BMPR1A

Bone morphogenetic protein receptor, type IA

3.8

4.3

0.9

CEBPA

CCAAT/enhancer-binding protein

11.4

19.1

0.6

COMP

Cartilage oligomeric matrix protein

17.2

10.8

1.6

DAAM2

Disheveled associated activator of morphogenesis 2

2.9

2.2

1.4

FZD4

Frizzled family receptor 4

13.4

7.5

1.8

GATA2

GATA-binding protein 2

7.1

9.4

0.7

IGFBP3

Insulin-like growth factor-binding protein 3

11.8

21.3

0.6

OMD

Osteomodulin

7.8

32.0

0.2

PPARG

Peroxisome proliferator-activated receptor gamma

79.9

14.0

5.7

PRELP

Proline/arginine-rich end leucine-rich repeat protein

19.1

87.1

0.2

SFRP4

Secreted frizzled-related protein 4

35.7

189.6

0.2

TNFAIP6

Tumor necrosis factor, alpha-induced protein 6

33.4

97.8

0.3

UGDH

Uridine diphosphoglucose dehydrogenase

2.1

3.1

0.7

  1. Relative fold change in expression identified as diagnostic for synovial fluid/Heberden’s node-multipotential stromal cells (SF/HN-MSCs) from statistical analysis (P ≤0.05, Mann-Whitney U). ICBM, normal iliac crest bone marrow.