Elevated C-reactive protein is associated with lower increase in knee muscle strength in patients with knee osteoarthritis: a 2-year follow-up study in the Amsterdam Osteoarthritis (AMS-OA) cohort

Sanchez-Ramirez, Diana C; van der Leeden, Marike; van der Esch, Martin; Roorda, Leo D; Verschueren, Sabine; van Dieën, Jaap H; Dekker, Joost; Lems, Willem F

doi:10.1186/ar4580

Table 2 Associations of C-reactive protein with muscle strength change in patients with knee osteoarthritis

From: Elevated C-reactive protein is associated with lower increase in knee muscle strength in patients with knee osteoarthritis: a 2-year follow-up study in the Amsterdam Osteoarthritis (AMS-OA) cohort

Independent factors	Muscle strength change, N-m/kg
	β	P value
CRP (crude)
Not elevated at baseline and at follow-up	Ref.
Elevated at baseline and not elevated at follow-up	0.05	0.51
Not elevated at baseline and elevated at follow-up	-0.09	0.22
Elevated at both times of assessment	-0.17	0.02
CRP^a,b
Not elevated at baseline and at follow-up	Ref.
Elevated at baseline and not elevated at follow-up	0.06	0.38
Not elevated at baseline and elevated at follow-up	-0.06	0.38
Elevated at both times of assessment	-0.17	0.02
CRP^a-c
Not elevated at baseline and at follow-up	Ref.
Elevated at baseline and not elevated at follow-up	0.06	0.44
Not elevated at baseline and elevated at follow-up	-0.06	0.42
Elevated at both times of assessment	-0.16	0.03
CRP^a-d
Not elevated at baseline and at follow-up	Ref.
Elevated at baseline and not elevated at follow-up	0.03	0.71
Not elevated at baseline and elevated at follow-up	-0.07	0.38
Elevated at both times of assessment	-0.18	0.02
CRP^a-e
Not elevated at baseline and at follow-up	Ref.
Elevated at baseline and not elevated at follow-up	0.01	0.92
Not elevated at baseline and elevated at follow-up	-0.09	0.25
Elevated at both times of assessment	-0.20	0.01
CRP^a-f
Not elevated at baseline and at follow-up	Ref.
Elevated at baseline and not elevated at follow-up	0.01	0.90
Not elevated at baseline and elevated at follow-up	-0.09	0.26
Elevated at both times of assessment	-0.19	0.01
CRP^a-g
Not elevated at baseline and at follow-up	Ref.
Elevated at baseline and not elevated at follow-up	0.01	0.93
Not elevated at baseline and elevated at follow-up	-0.09	0.25
Elevated at both times of assessment	-0.19	0.01
CRP^a-h
Not elevated at baseline and at follow-up	Ref.
Elevated at baseline and not elevated at follow-up	0.05	0.57
Not elevated at baseline and elevated at follow-up	-0.09	0.25
Elevated at both times of assessment	-0.21	0.01

This linear regression analysis used muscle strength change as a dependent factor. All of the models were adjusted for baseline muscle strength. Additionally, confounders adjusting the model were ^aage, ^bgender, ^ccomorbidities change, ^dnon-steroidal anti-inflammatory drug change, ^ebody mass index change, ^fWestern Ontario and McMaster Universities Osteoarthritis pain change, ^gKellgren-Lawrence score change, and ^hphysical activity follow-up. Reduce patient numbers in the multivariate linear regression analyses due to random missing in the outcome measure or selected predictors. CRP, C-reactive protein; Ref., reference.

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ISSN: 1478-6362

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