Figure 1

Expression of CXCL10 in C-protein-induced myositis (CIM). (A) Immunohistochemistry of CXCL9, CXCL10 and CXCL11 in the muscle of CIM (×400). In the inflammatory lesion of CIM, CXCL10 was strongly stained whereas CXCL9 or CXCL11 was weakly stained. (B) Serum level of CXCL10 in normal mice and CIM mice. The level of CXCL10 was measured by ELISA in the sera of normal mice (n = 10) and CIM mice (n = 10) at 3 weeks after induction. The serum level of CIM was more elevated in CIM than in normal mice (normal mouse, 14.3 ± 5.3 pg/ml versus CIM, 368.5 ± 135.6 pg/ml, P <0.001). The horizontal lines indicate the mean.