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Table 4 Relative risk of acute coronary syndrome associated with tumour necrosis factor inhibitor a

From: The risk of acute coronary syndrome in rheumatoid arthritis in relation to tumour necrosis factor inhibitors and the risk in the general population: a national cohort study

Strata Ever-exposed Actively on TNFi
TNFi-exposed RA (ACS events/person-years) Biologic-naïve RA (ACS events/person-years) TNFi-exposed vs. biologic-naïve b(HR (95% CI)) TNFi-exposed RA (ACS events/person-years) Biologic-naïve RA (ACS events/person-years) TNFi-exposed vs. biologic-naïve b(HR (95% CI))
Female 143/24,978 420/57,583 0.85 (0.70 to 1.03) 79/18,170 282/42188 0.70 (0.54 to 0.90)
Male 78/7,643 260/17,682 0.74 (0.57 to 0.96) 58/5,885 194/13466 0.72 (0.53 to 0.96)
Age <65 yr 111/25,208 331/55,041 0.76 (0.61 to 0.94) 74/18,969 250/42089 0.68 (0.52 to 0.89)
Age ≥65 yr 110/7,413 349/20,227 0.87 (0.70 to 1.07) 63/5,086 226/13,565 0.75 (0.57 to 0.99)
Cardiovascular risk factor present 70/5,520 259/15,321 0.78 (0.60 to 1.02) 43/3,898 185/11,154 0.67 (0.48 to 0.93)
No previous cardiovascular risk factor 151/27,101 421/59,946 0.86 (0.71 to 1.04) 94/20,157 291/44,500 0.77 (0.61 to 0.97)
TNFi start 2001 to 2005 175/22,505 517/48,870 0.81 (0.68 to 0.97) 106/15,627 344/33,726 0.72 (0.58 to 0.90)
TNFi start 2006 to 2010 46/10,116 163/26,398 0.77 (0.55 to 1.07) 31/8,427 132/21,928 0.64 (0.43 to 0.95)
  1. aACS, Acute coronary syndrome; RA, Rheumatoid arthritis; TNF, Tumour necrosis factor. bThe analyses were adjusted for age, sex and county of residence. The analysis stratified for sex was adjusted for age and county of residence. ‘Cardiovascular risk factor’ refers to any previous diagnosis of diabetes, hypertension and cerebrovascular and/or other atherosclerotic disease.