Table 4 Relative risk of acute coronary syndrome associated with tumour necrosis factor inhibitor a
Strata | Ever-exposed | Actively on TNFi | ||||
|---|---|---|---|---|---|---|
TNFi-exposed RA (ACS events/person-years) | Biologic-naïve RA (ACS events/person-years) | TNFi-exposed vs. biologic-naïve b(HR (95% CI)) | TNFi-exposed RA (ACS events/person-years) | Biologic-naïve RA (ACS events/person-years) | TNFi-exposed vs. biologic-naïve b(HR (95% CI)) | |
Female | 143/24,978 | 420/57,583 | 0.85 (0.70 to 1.03) | 79/18,170 | 282/42188 | 0.70 (0.54 to 0.90) |
Male | 78/7,643 | 260/17,682 | 0.74 (0.57 to 0.96) | 58/5,885 | 194/13466 | 0.72 (0.53 to 0.96) |
Age <65 yr | 111/25,208 | 331/55,041 | 0.76 (0.61 to 0.94) | 74/18,969 | 250/42089 | 0.68 (0.52 to 0.89) |
Age ≥65 yr | 110/7,413 | 349/20,227 | 0.87 (0.70 to 1.07) | 63/5,086 | 226/13,565 | 0.75 (0.57 to 0.99) |
Cardiovascular risk factor present | 70/5,520 | 259/15,321 | 0.78 (0.60 to 1.02) | 43/3,898 | 185/11,154 | 0.67 (0.48 to 0.93) |
No previous cardiovascular risk factor | 151/27,101 | 421/59,946 | 0.86 (0.71 to 1.04) | 94/20,157 | 291/44,500 | 0.77 (0.61 to 0.97) |
TNFi start 2001 to 2005 | 175/22,505 | 517/48,870 | 0.81 (0.68 to 0.97) | 106/15,627 | 344/33,726 | 0.72 (0.58 to 0.90) |
TNFi start 2006 to 2010 | 46/10,116 | 163/26,398 | 0.77 (0.55 to 1.07) | 31/8,427 | 132/21,928 | 0.64 (0.43 to 0.95) |