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Table 1 List of the 19 systemic lupus erythematosus loci included in this study and their association with systemic lupus erythematosus in our samples a

From: Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus

SNP Gene locus b Chromosome Position SLE c Control c OR (95% CI) P-value
rs2476601 PTPN22 1 114377568 0.099 0.074 1.37 (1.15 to 1.63) 4.3 × 10−4
rs1801274 FCGR2A 1 161479745 0.509 0.475 1.15 (1.04 to 1.27) 6.2 × 10−3
rs2205960 TNFSF4 1 173191475 0.264 0.217 1.29 (1.15 to 1.45) 1.0 × 10−5
rs7574865 STAT4 2 191964633 0.323 0.233 1.57 (1.41 to 1.76) 1.2 × 10−15
rs6445975 PXK 3 58370177 0.268 0.231 1.22 (1.09 to 1.37) 6.2 × 10−4
rs17266594 BANK1 d 4 98488450 0.749 0.711 1.21 (1.09 to 1.36) 6.6 × 10−4
rs3131379 MSH5 6 31721033 0.145 0.072 2.18 (1.85 to 2.58) 4.2 × 10−21
rs729302 IRF5 7 122930164 0.744 0.690 1.31 (1.17 to 1.46) 2.5 × 10−6
rs10488631 IRF5 d 7 128594183 0.183 0.101 1.99 (1.72 to 2.31) 1.8 × 10−20
rs10954213 IRF5 7 128589427 0.680 0.641 1.19 (1.07 to 1.32) 1.1 × 10−3
rs13277113 C8orf13-BLK 8 11349186 0.308 0.247 1.35 (1.21 to 1.51) 8.1 × 10−8
rs4963128 KIAA1542 11 589564 0.698 0.656 1.21 (1.09 to 1.34) 5.0 × 10−4
rs1143679 ITGAM 16 31276811 0.236 0.158 1.65 (1.45 to 1.87) 7.0 × 10−15
rs2304256 TYK2 19 10475652 0.766 0.725 1.24 (1.11 to 1.39) 2.0 × 10−4
rs5754217 UBE2L3 22 21939675 0.253 0.216 1.24 (1.10 to 1.39) 3.6 × 10−4
rs2230926 TNFAIP3 6 138196066 0.074 0.040 1.89 (1.52 to 2.35) 8.5 × 10−9
rs573775 ATG5 6 106764866 0.297 0.267 1.16 (1.04 to 1.29) 8.8 × 10−3
rs2187668 HLA-DQA1 6 32605884 0.200 0.106 2.11 (1.83 to 2.43) 1.2 × 10−25
rs10798269 1q25.1 1 173309713 0.729 0.685 1.24 (1.11 to 1.38) 1.3 × 10−4
  1. aSLE, Systemic lupus erythematosus; SNP, Single-nucleotide polymorphism. bThe 13 first loci are shared with those studied by Hughes et al. [1]. cRisk allele frequencies in patients with SLE (n = 1,457) and healthy controls (n = 1,728). d r2 = 0.94 with rs10516487 used for BANK1 by Hughes et al. [9] and r2 = 0.94 for rs2070197 used for IRF5 by Hughes et al. [9].