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Table 3 Multivariate analysis of covariate effects on the modified Rodnan skin score in a subsample of women with early disease (n = 370)

From: Effect of menopause on the modified Rodnan skin score in systemic sclerosis

Covariate Multivariate effect estimate (95% CI)
Menopausal status  
 Premenopausal Reference
 Postmenopausal −3.36 (−5.87, −0.85)
Disease subtype  
 Diffuse Reference
 Limited −13.50 (−16.10, −10.99)
Menopause*disease typeb 1.91 (−0.83, 4.65)
Time since baseline (years) −0.13 (−0.40, 0.14)
Disease duration at baseline (years) −0.47 (−0.98, 0.04)
Age at disease onset (years) 0.04 (0.00, 0.08)
Race/ethnicity  
 White Reference
 Black −0.64 (−2.85, 1.11)
 Other −0.87 (−1.42, 0.50)
Smoking  
 Never Reference
 Ever 0.86 (−0.55, 2.15)
Oral contraceptive pill  
 Past/never Reference
 Current −0.78 (−2.15, 0.43)
Hormone replacement therapy  
 Past/never Reference
 Current 0.08 (−2.84, 3.00)
DMARDsc  
 Past/never Reference
 Current 0.10 (−1.61, 1.81)
Cyclophosphamide  
 Never Reference
 Ever −0.33 (−2.31, 1.65)
  1. bInteraction term between menopausal status and disease subtype. DMARDs, cdisease- modifying antirheumatic drugs.