Skip to main content
Figure 1 | Arthritis Research & Therapy

Figure 1

From: Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis

Figure 1

The effect of local intra-articular and systemic administration of IL-1 receptor antagonist (IL-1Ra) and soluble TNF receptor II (sTNFRII) on degenerative changes in joint tissues following articular fracture. Histologic images of knee joints stained with Safranin-O (red) and fast green (green) following fracture (F = femur, T = tibia, M = meniscus, white arrow = articular fracture, yellow arrow = fibrocartilage), and total joint Mankin score of arthritic degenerative changes in joint tissues for contralateral control and fractured limbs following local intra-articular (IA) administration of saline, IL-1Ra and sTNFRII (A-B) and systemic administration of saline, IL-1Ra and sTNFRII (C-D). Data presented as mean + standard deviation (*significant difference between limbs, #significant differences between treatment groups).

Back to article page