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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis

Figure 2

The effect of local intra-articular and systemic administration of IL-1 receptor antagonist (IL-1Ra) and soluble TNF receptor II (sTNFRII) on synovial inflammation of the knee joint following articular fracture. Synovitis scores of lateral and medial sides of knee joints for contralateral control and fractured limbs and histologic images of synovium stained with H&E on the medial side of joint with femur (F), tibia (T), and synovial lining near medial meniscus (M) identified by black arrows following local intra-articular (IA) administration of saline, IL-1Ra and sTNFRII (A-B) and systemic administration of saline, IL-1Ra and sTNFRII (C-D). Data presented as mean + standard deviation (*significant difference between limbs, #significant difference between treatment groups).

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Arthritis Research & Therapy

ISSN: 1478-6362

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