The effect of local intra-articular and systemic administration of IL-1 receptor antagonist (IL-1Ra) and soluble TNF receptor II (sTNFRII) on bone morphology of the tibial plateau following articular fracture. (A) Bone fraction and (B) bone density of the fractured limb as normalized to the contralateral control limb of each mouse for the tibial. Data presented as mean ± standard deviation (*difference between paired limbs is significantly different to zero, #significant difference between means in treatment groups). Representative axial micro computed tomography (microCT) images of the tibial plateau following (C) local intra-articular and (D) systemic administration of IL-1Ra and sTNFRII at 8 weeks following articular fracture. Bar, 1 mm.