Table 1 Serum drug levels during treatment
| Â | Time, days | Local saline | Local drug |
|---|---|---|---|
Serum levels of locally delivered IL-1Ra, pg/ml | 1 | 180 | 1,460 |
| Â | 3 | 151 | 271 |
| Â | 14 | 23 | 18 |
| Â | 15 | 6 | 10 |
Serum levels of locally delivered sTNFRII, ng/ml | 1 | NA | 803 |
| Â | 3 | NA | 128 |
| Â | 14 | 0.01 | 0.2 |
| Â | 18 | NA | 0.6 |
Serum levels of systemically delivered IL-1Ra, pg/ml | 28 | 3 | 36,000 |
Serum levels of systemically delivered sTNFRII, ng/ml | 1 | 0.01 | 5,615 |
| Â | 7 | 0.01 | 3,789 |
| Â | 14 | 0.01 | 44 |
| Â | 28 | 0.01 | 97 |
| Â | 42 | 0.01 | 0.11 |
| Â | 56 | 0.01 | 0.01 |