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Table 1 Serum drug levels during treatment

From: Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis

  Time, days Local saline Local drug
Serum levels of locally delivered IL-1Ra, pg/ml 1 180 1,460
  3 151 271
  14 23 18
  15 6 10
Serum levels of locally delivered sTNFRII, ng/ml 1 NA 803
  3 NA 128
  14 0.01 0.2
  18 NA 0.6
Serum levels of systemically delivered IL-1Ra, pg/ml 28 3 36,000
Serum levels of systemically delivered sTNFRII, ng/ml 1 0.01 5,615
  7 0.01 3,789
  14 0.01 44
  28 0.01 97
  42 0.01 0.11
  56 0.01 0.01
  1. NA- sample was Not Available for testing.