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Table 2 Global joint changes following articular fracture: correlation between arthritic changes, synovial inflammation and bone morphology

From: Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis

  Lateral synovitis score Medial synovitis score   Lateral synovitis score Medial synovitis score
Control limb    Fractured limb   
Mankin total joint score r s = 0.06, P = 0.68 r s = 0.19, P = 0.17 Mankin total joint score r s = 0.10, P = 0.47 r s = 0.48, P= 0.001
Lateral Mankin score r s = 0.16, P = 0.26 r s = 0.17, P = 0.24 Lateral Mankin score r s = 0.06, P = 0.68 rs = 0.14, P = 0.31
Medial Mankin score r s = -0.07, P = 0.60 r s = 0.10, P = 0.46 Medial Mankin score r s = 0.16, P = 0.27 r s = 0.61, P= 0.001
  Mankin total joint score Lateral synovitis score Medial synovitis score
  Control limb Fractured limb Control limb Fractured limb Control limb Fractured limb
Tibial plateau bone volume, mm3 r s = -0.30, P= 0.02 r s = -0.39, P= 0.002 r s = 0.10, P = 0.43 r s = 0.13, P = 0.32 r s = 0.11, P = 0.38 r s = -0.25, P= 0.05
Tibial Plateau bone density, mg/cm3 r s = -0.08, P = 0.55 r s = -0.29, P= 0.02 r s = 0.10, P = 0.43 r s = -0.37, P= 0.004 r s = 0.10, P = 0.46 r s = -0.48, P= 0.001
Femoral condyle cancellous bone fraction r s = -0.07, P = 0.50 r s = -0.48, P= 0.001 r s = 0.09, P = 0.36 r s = -0.27, P= 0.006 r s = 0.16, P = 0.10 r s = -0.45, P= 0.001
Tibial metaphysis bone density, mg/cm3 r s = 0.22, P = 0.08 r s = -0.11, P = 0.40 r s = 0.13, P = 0.34 r s = -0.30, P= 0.02 r s = 0.06, P = 0.60 r s = -0.20, P = 0.12
  1. Significant Spearman correlations, rs, between Mankin scores of arthritic changes, synovitis scores, and bone morphology parameters following articular fracture in the knee indicate a complex interaction among joint tissues with PTA disease progression (correlation coefficients in boldface text are statistically significant, P <0.05).