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Table 3 Biomarkers and cytokines

From: Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis

  Local - saline Local - IL-1Ra Local - sTNFRII P(Kruskal-Wallis) Systemic - saline Systemic - IL1-Ra Systemic - sTNFRII P(Kruskal-Wallis)
Serum osteocalcin, ng/ml 7.3 ± 9.0 11.1 ± 6.7 111.4 ± 199.5§ 0.08 11.1 ± 11.3 10.6 ± 9.9 10.6 ± 9.9 0.93
Serum CTX-I, ng/ml 17.3 ± 7.4a 15.9 ± 3.6a 34.2 ± 24.6b 0.03 22.5 ± 16.6 23.0 ± 14.1 19.9 ± 9.9 0.73
Serum free active (FA) TGF-β1, pg/ml 19.1 ± 8.2 20.7 ± 10.3 22.4 ± 11.4 0.97 22.8 ± 11.9 34.3 ± 8.0§ 20.2 ± 19.1 0.07
Serum total TGF-β1, pg/ml 121,025 ± 45,854a 108,251 ± 17,183a 84,573 ± 12,760b 0.004 95,781 ± 24,239 99,868 ± 4,063 90,003 ± 11,717 0.18
Serum FA/total TGF-β1 (x 10-3) 0.18 ± 0.09 0.19 ± 0.08 0.27 ± 0.14 0.50 0.23 ± 0.10a,b 0.34 ± 0.07a 0.24 ± 0.25b 0.048
Serum CTX-II 5.7 ± 10.1 5.7 ± 7.7 3.8 ± 5.3 0.83 2.4 ± 3.1 1.7 ± 4.4 2.7 ± 4.6 0.88
Serum IL-6, pg/ml 32.5 ± 41.5a,b 6.3 ± 2.8a 67.0 ± 103b 0.004 17.6 ± 35.6 57.9 ± 78.0§ 48.3 ± 77.2§ 0.09
SF IL-6 control limb, pg/ml 1,294 ± 319a,b 1,348 ± 531a 626 ± 505b 0.02 523 ± 657 1,333 ± 365§ 1,197 ± 1,675§ 0.08
SF IL-6 fractured limb, pg/ml 1,513 ± 977a,b 1,238 ± 299a 820 ± 500b 0.04 730 ± 595a 1,370 ± 587b 653 ± 486a 0.04
  1. Serum and synovial fluid (SF) measures of the bone turnover markers osteocalcin and C-terminal telopeptides of type I collagen (CTX-I), cartilage derived CTX-II, joint-tissue-related growth factor TGF-β1, and the cytokine IL-6. Data are presented as mean ± standard deviation. Data with different letters are statistically different from each other (P <0.05) as measured by Kruskal-Wallis with multiple comparison of the mean ranks. P - values of the measures with significant differences (P <0.05) are shown in boldface text. §Trend (P ≤0.09).