Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice

Table 2 Odds ratio for the association of antibody-positive patients within the different HLA-DRB1 groups

	No SE (n = 47)	HLA-DRB1*01 (n = 50)		HLA-DRB1*04 (n = 127)
Antigen	Frequency of positive patients (%)	Frequency of positive patients (%)	Odds ratio DR*01 vs. no SE	Frequency of positive patients (%)	Odds ratio DR*04 vs. no SE	Odds ratio DR04 vs. DR01
C1 sera	14.9	16	1.088, 95% CI 0.3613 to 0.280	11.8	0.7653, 95% CI0.291 to 2.013	0.703, 95% CI 0.278 to 1.780
C1 SF	10.6	22	2.369, 95% CI 0.755 to 7.436	25.2	2.829, 95% CI 1.030 to 7.771	1.194, 95% CI 0.547 to 2.605
J1 sera	6.4	14	2.388, 95% CI 0.579 to 9.845	5.5	0.856, 95% CI 0.212 to 3.457	0.3583, 95% CI 0.119 to 1.081
J1 SF	6.4	8	1.275, 95% CI 0.361 to 3.280	7.1	1.119, 95% CI 0.289 to 4.324	0.469, 95% CI 0.164 to 1.336
U1 sera	42.6	38	0.827, 95% CI 0.367 to 1.865	48	1.227, 95% CI 0.624 to 2.413	1.483, 95% CI 0.759 to 2.898
U1 SF	68.1	82	2.135, 95% CI 0.828 to 5.506	76.4	1.516, 95% CI 0.7245 to 3.169	0.710, 95% CI 0.310 to 1.627
CitC1 sera	27.6	26	0.919, 95% CI 0.374 to 2.258	53	2.921, 95% CI 1.410 to 6.049	3.178, 95% CI 1.544 to 6.541
CitC1 SF	17	26	1.713, 95% CI 0.637 to 4.606	48.8	4.650, 95% CI 2.014 to 10.74	2.715, 95% CI 1.319 to 5.586

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