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Table 1 Demographic and clinical characteristics a

From: Interferon regulatory factor 5 genetic variants are associated with cardiovascular disease in patients with rheumatoid arthritis

Clinical features % ( n/ N) or mean ± SD
Patients 2,137
Main characteristics  
  Age at disease onset (yr) 53 ± 14.8
  Follow-up duration (yr) 12.5 ± 8.25
  Females (%) 75.1
  Rheumatoid factor–positiveb 68.3 (1,413/2,070)
  Anti-CCP antibody–positive 57.3 (1,024/1,785)
  Shared epitope–positive 62.6 (734/1,173)
Erosions 54.4 (866/1,591)
  Extraarticular manifestationsc 31.3 (481/1,537)
Cardiovascular risk factors  
  Hypertension 40.3 (846/2,100)
  Diabetes mellitus 13.1 (275/2,100)
  Dyslipidemia 38.3 (805/2,100)
  Obesity 19.6 (413/2,100)
  Smoking habit 27.4 (576/2,100)
Patients with cardiovascular events (total) 18.2 (390/2,137)
  Ischemic heart disease 8.5 (181/2,137)
  Heart failure 5.7 (122/2,137)
  Cerebrovascular accident 5.6 (120/2,137)
  Peripheral arteriopathy 2.8 (60/2,137)
  1. aCCP: Cyclic citrullinated peptide; SD: Standard deviation. bAt least two determinations were required for analysis of this result. cExtraarticular manifestations of disease (if RA patients had at least one of the following manifestations: nodular disease: Felty’s syndrome, pulmonary fibrosis, rheumatoid vasculitis, secondary Sjögren’s syndrome) [4].