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Table 2 Factors associated with cardiovascular events in a series of 2,137 rheumatoid patients a

From: Interferon regulatory factor 5 genetic variants are associated with cardiovascular disease in patients with rheumatoid arthritis

Variables   HR (95% CI) P-values P-valuesb
Males (reference: females)   1.42 (1.07 to 1.87) 0.015  
Age at RA diagnosis (by each year)   1.07 (1.06 to 1.09) <0.001  
Hypertension   1.40 (1.029 to 1.92) 0.032  
Diabetes mellitus   1.18 (0.83 to 1.68) 0.344  
Obesity   0.93 (0.67 to 1.31) 0.702  
Dyslipidemia   1.42 (1.05 to 1.93) 0.022  
Smoking   1.58 (1.26 to 1.99) <0.001  
rs2004640c TT 1 (reference)
  TG 1.07 (0.79 to 1.45) 0.664 0.670
  GG 0.59 (0.38 to 0.92) 0.020 0.034
rs2070197c TT 1 (reference)
  TC 1.16 (0.69 to 1.95) 0.58
  CC 1.32 (0.32 to 5.52) 0.39
rs10954213c AA 1 (reference)
  AG 0.95 (0.71 to 1.26) 0.73 0.738
  GG 0.58 (0.36 to 0.95) 0.03 0.049
  1. aCI: Confidence interval; HR: Hazard ratio; RA: Rheumatoid arthritis. bP-values estimated on the basis of 10,000 replications. cAdjusted for sex, age at time of rheumatoid arthritis diagnosis and traditional cardiovascular disease risk factors (hypertension, diabetes mellitus, dys lipidemia, obesity, smoking habit).