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Table 2 Factors associated with cardiovascular events in a series of 2,137 rheumatoid patients a

From: Interferon regulatory factor 5 genetic variants are associated with cardiovascular disease in patients with rheumatoid arthritis

Variables

 

HR (95% CI)

P-values

P-valuesb

Males (reference: females)

 

1.42 (1.07 to 1.87)

0.015

 

Age at RA diagnosis (by each year)

 

1.07 (1.06 to 1.09)

<0.001

 

Hypertension

 

1.40 (1.029 to 1.92)

0.032

 

Diabetes mellitus

 

1.18 (0.83 to 1.68)

0.344

 

Obesity

 

0.93 (0.67 to 1.31)

0.702

 

Dyslipidemia

 

1.42 (1.05 to 1.93)

0.022

 

Smoking

 

1.58 (1.26 to 1.99)

<0.001

 

rs2004640c

TT

1 (reference)

 

TG

1.07 (0.79 to 1.45)

0.664

0.670

 

GG

0.59 (0.38 to 0.92)

0.020

0.034

rs2070197c

TT

1 (reference)

 

TC

1.16 (0.69 to 1.95)

0.58

 

CC

1.32 (0.32 to 5.52)

0.39

rs10954213c

AA

1 (reference)

 

AG

0.95 (0.71 to 1.26)

0.73

0.738

 

GG

0.58 (0.36 to 0.95)

0.03

0.049

  1. aCI: Confidence interval; HR: Hazard ratio; RA: Rheumatoid arthritis. bP-values estimated on the basis of 10,000 replications. cAdjusted for sex, age at time of rheumatoid arthritis diagnosis and traditional cardiovascular disease risk factors (hypertension, diabetes mellitus, dys lipidemia, obesity, smoking habit).