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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Inflammatory expression profiles in monocyte-to-macrophage differentiation in patients with systemic lupus erythematosus and relationship with atherosclerosis

Figure 2

Tree dendrogram derived from expression patterns of a previously described 344-gene atherosclerosis signature in systemic lupus erythematosus (SLE) patients. Red boxes above an individual’s expression heatmap represent the presence of the atherosclerosis phenotype, and a black box denotes its absence. Below each cluster, the individuals are stratified as having or not having active SLE (average SLEDAI of more than 4), atherosclerosis phenotype (groups identified with the phenotype had greater than 70% of individuals with the atherosclerosis phenotype), SLE damage (average SLICC/ACR-DI of more than 2), and traditional cardiovascular risk factors, including an average of at least one of the four risk factors of hypertension, dyslipidemia, diabetes, and smoking. SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; SLICC/ACR-DI, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index.

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