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Table 2 Biologic processes in which genes associated with differential expression during monocyte-to-macrophage differentiation

From: Inflammatory expression profiles in monocyte-to-macrophage differentiation in patients with systemic lupus erythematosus and relationship with atherosclerosis

Biological process Genes in PANTHER database Observed Expected χ2p value
Immune system process 2,628 127 52.93 9.98 × 10-22
Signal transduction 4,191 147 84.41 5.75 × 10-13
Apoptosis 966 45 19.45 2.18 × 10-7
B cell-mediated immunity 314 21 6.32 2.49 × 10-6
Lipid metabolic process 1,119 46 22.54 4.59 × 10-6
Intracellular signaling 1,568 58 31.58 6.08 × 10-6
Macrophage activation 305 19 6.14 1.97 × 10-5
Response to interferon-gamma 105 10 2.11 6.83 × 10-5
Induction of apoptosis 358 19 7.21 1.58 × 10-4
Carbohydrate metabolism 952 35 19.17 5.33 × 10-4
Complement activation 162 11 3.26 5.43 × 10-4
  1. PANTHER, Protein Analysis Through Evolutionary Relationships.