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Table 1 Joint inflammation and cartilage damage on day 3 of antigen-induced arthritis

From: Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice

Species

Hyperplasia

Synovial infiltrate

Exudate

Cartilage depletion

Arthritis index

Syndecan 3−/−

2.07 ± 0.23

2.67 ± 0.67**

0.63 ± 0.24

0.63 ± 0.24*

6.00 ± 0.75**

Syndecan-3+/+

2.57 ± 0.15

3.97 ± 0.24

1.40 ± 0.31

1.40 ± 0.27

9.33 ± 0.74

  1. Synovial hyperplasia of the lining layer, synovial infiltration of the sublining by leukocytes, exudate in the joint cavity, and loss of proteoglycan from the articular cartilage were observed in haematoxylin/eosin and haematoxylin/safrinin-O-stained sections. Sections were scored blind by two independent observers from 0 to 3 (hyperplasia, exudate and cartilage depletion) or 0 to 5 (infiltrate). The arthritis index is the sum of all observations. *P <0.05 and **P <0.01 of the parameter compared to wild-type mice using Mann-Whitney U test.
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Arthritis Research & Therapy

ISSN: 1478-6362

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