Joint inflammation in glucose-6-phosphate isomerase–induced arthritis. (A) Photographs showing inflammation in fore- and hindpaws of arthritic mice (two at right) and nonimmunized control animals (two at left). (B) Clinical course of inflammatory arthritis in DBA/1 mice (n = 7). GPI, Glucose-6-phosphate isomerase induction. (C) Arthritis was associated with destruction of bone. Shown is a representative image of metatarsal bone revealing cortical bone lesions (arrows) and infiltration of immune cells to the sites of inflammation. B, Bone; BM, Bone marrow; J, Joint; CI, Cellular infiltrate; MT, Metatarsal. Original magnification = 20× (left) and 200× (right).