Quantification bone parameters on high-resolution μCT images. (A) Quantification of the surface of all five metatarsal bones (MT1 to MT5) revealed no difference in bone structure between naïve mice and those with acute arthritis (day 14 (d14)), when inflammation was at its maximum. In contrast, bone surface area was significantly increased in chronic arthritis (d28 and d35). In late chronic arthritis (d50), surface area declined to preinflammation levels. (B) Volumes of metatarsal bones were almost unaffected by disease pathogenesis, except for significant increases in MT1, MT4 and MT5 at d28 and significant decreases in MT2 and MT3 at d50 (n = 6 to 12 paws per time point). *P < 0.05, **P < 0.01, ***P < 0.001.