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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren’s syndrome

Figure 6

Stat1 expression is significantly reduced in TLR7/8 stimulated monocyte-derived dendritic cells from primary Sjögren’s syndrome patients. (A), (B) Representative western blots for Stat1α, p-Stat1α (Y701), p-Stat1α (S727) and glyceraldehyde 3-phosphatase dehydrogenase (GAPDH) expression in mature monocyte-derived dendritic cells (moDC) from primary Sjögren’s syndrome (pSS) patients (n = 4) and controls (n = 4). (C) Stat1 expression in immature and mature moDC from patients (n = 8) and controls (n = 8). (D) p-Stat1α (S727) expression in immature and mature moDC from patients (n = 8) and controls (n = 8). (E) p-Stat1α (Y701) expression in immature and mature moDC from patients (P immature n = 7 and P mature n = 8) and controls (C immature n = 5 and C mature n = 8). Relative expression levels are presented as arbitrary units and were calculated as the percentage of band density normalized to GAPDH expression in relation to a standard sample used on all blots (set to 100%).

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