|
Cytokine (pg/ml)
|
Patients immature (n = 21)
|
Controls immature (n = 17)
|
Patients mature (n = 20)
|
Controls mature (n = 16)
|
|---|
|
IL-7
|
30.9 ± 11.0
|
35.3 ± 29.8
|
31.4 ± 11.0
|
40.3 ± 16.2*
|
|
IL-12p40
|
703.9 ± 878.8
|
498.9 ± 362.8
|
3847.9 ± 5867.8
|
796.3 ± 326.8**
|
|
IL-17
|
86.0 ± 22.1
|
83.2 ± 31.9
|
76.6 ± 15.1
|
101.5 ± 39.4*
|
|
TNFα
|
28.9 ± 22.1
|
24.3 ± 8.8
|
53.9 ± 20.5
|
39.8 ± 17.9*
|
|
Interferon gamma
|
18.3 ± 7.9
|
24.1 ± 12.5
|
20.5 ± 8.9
|
29.1 ± 9.3**
|
|
MIP-1α
|
298.5 ± 138.8
|
304.3 ± 146.5
|
398.7 ± 201.3
|
304.6 ± 228.5*
|
- Only cytokines with a significant different value are shown. Data presented as mean ± standard deviation. IL, interleukin; MIP, macrophage inflammatory protein; moDC, monocyte-derived dendritic cells; pSS, primary Sjögren’s syndrome; TLR, toll-like receptor; TNFα, tumor necrosis factor alpha. A significant difference (*P < 0.05 and **P < 0.01) for the levels of six different cytokines was found when comparing mature moDC from pSS patients with mature moDC from healthy controls.
