Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren’s syndrome

Table 2 Comparison of cytokines secreted by immature or TLR7/8 stimulated mature moDC from pSS patients and controls analyzed by multiplex Luminex analyses

Cytokine (pg/ml)	Patients immature (n = 21)	Controls immature (n = 17)	Patients mature (n = 20)	Controls mature (n = 16)
IL-7	30.9 ± 11.0	35.3 ± 29.8	31.4 ± 11.0	40.3 ± 16.2*
IL-12p40	703.9 ± 878.8	498.9 ± 362.8	3847.9 ± 5867.8	796.3 ± 326.8**
IL-17	86.0 ± 22.1	83.2 ± 31.9	76.6 ± 15.1	101.5 ± 39.4*
TNFα	28.9 ± 22.1	24.3 ± 8.8	53.9 ± 20.5	39.8 ± 17.9*
Interferon gamma	18.3 ± 7.9	24.1 ± 12.5	20.5 ± 8.9	29.1 ± 9.3**
MIP-1α	298.5 ± 138.8	304.3 ± 146.5	398.7 ± 201.3	304.6 ± 228.5*

Only cytokines with a significant different value are shown. Data presented as mean ± standard deviation. IL, interleukin; MIP, macrophage inflammatory protein; moDC, monocyte-derived dendritic cells; pSS, primary Sjögren’s syndrome; TLR, toll-like receptor; TNFα, tumor necrosis factor alpha. A significant difference (*P < 0.05 and **P < 0.01) for the levels of six different cytokines was found when comparing mature moDC from pSS patients with mature moDC from healthy controls.

ISSN: 1478-6362