Histologic scores, expression of chemokines and adhesion molecules and lymphocyte counts before and after single infusion of infliximab. (a) and (b) Histologic scores of knee synovial biopsies before (shaded bar) and after (open bar) treatment by chemokine or adhesion molecule. (c) Circulating lymphocytes; infliximab 10 mg/kg (closed square ■), infliximab 1 mg/kg (closed triangle ▲), and placebo (open circle ○). (d) Change in serum E-selectin concentrations; infliximab 1 mg/kg (closed triangle ▲), infliximab 10 mg/kg (closed square ■), and placebo (open circle ○). Panel a, data from Taylor PC et al. ; panel b, data from Tak PP et al. ; Panels c and d, adapted with permission from Paleolog et al. . Copyright 1996, American College of Rheumatology.