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Table 1 Depending on T-cell stimulus, various products are induced in monocytes upon cell–cell contact

From: The role of human T-lymphocyte-monocyte contact in inflammation and tissue destruction

Stimulus Type of T cell Type of monocyte Products References
PHA/PMA PB TL, HUT-78 cells, Jurkat cells, synovial and PB T cell clones: CD4+; CD8+; Th1; and Th2 PB monocytes, THP-1 cells TNF-α, IL-1β, IL-6, IL-8, IL-1α, IL-1Ra, TNFsRs, MMP-1 MMP-9, TIMP-1 [26, 8, 62]
PdBu/ionomycine PB TL PB monocytes TNF-α, IL-10 [19]
anti-CD3 PB TL, synovial T cells PB monocytes, THP-1 cells TNF-α, IL-10, IL-1β; MMP-1 [4, 12, 19, 22, 62]
anti-CD3 and anti-CD28 or specific Ag Th1 cell clones THP-1 cells IL-1β, low IL-1Ra [7]
anti-CD3 and anti-CD28 or specific Ag Th2 cell clones THP-1 cells IL-1Ra, low IL-1β [7]
Cytokines* PB TL, synovial T cells, Th1 and Th2 cell clones PB monocytes TNF-α, IL-1β [912, 20, 63]
Anti-CD3 PB TL PMA/IFN-γ-treated U937 cell TNF-α, IL-10, IL-12 and IL-4 [64]
  1. *IL-2 or IL-15 alone or in combination with IL-6 and TNF-α. Ag, antigen; MMP, matrix metalloproteinase; PB, peripheral blood; PHA, phytohemagglutinin; PMA, phorbol myristate acetate; Th, T helper cell; TIMP, tissue inhibitor of matrix metalloproteinases; TL, T lymphocyte; TNF, tumor necrosis factor; TNFsRs, TNF soluble receptors. Modified and published with permission from European Cytokine Network[13].