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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Interactions between leukocytes and endothelial cells in gout: lessons from a self-limiting inflammatory response

Figure 1

Kinetics of endothelial E-selectin expression, entry of neutrophils and mononuclear cells into the tissues, and erythema in pig skin after injection of monosodium urate (MSU) crystals. Note that E-selectin expression and leukocyte trafficking have returned to near baseline before maximal erythema is seen at 24 hours, indicating a vascular downregulation of the inflammatory response. Erythema subsides spontaneously after 24 hours, in spite of the continued presence of MSU crystals in the tissues, suggesting extravascular downregulating mechanisms (modified from [26], with kind permission from the British Journal of Rheumatology).

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Arthritis Research & Therapy

ISSN: 1478-6362

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