From: Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics
Variant | MMP-1 | MMP-2 | MMP-3 |
N-TIMP-1 | 3.0 | 1.1 | 1.9 |
Thr2 to serine | 25 | 2.1 | 0.5 |
Thr2 to glycine | 18 × 103 | 103 × 103 | 1.4 × 103 |
Thr2 to alanine | 2090 | 307 | 126 |
Thr2 to leucine | 93 | 1.0 | 3.2 |
Thr2 to isoleucine | 262 | 5.6 | 20 |
Thr2 to valine | 1.6 | 4.5 | 3.0 |
Thr2 to methionine | 11 | 0.7 | 0.7 |
Thr2 to phenylalanine | 42 | 17 | 13 |
Thr2 to asparagine | 1970 | 16 | 44 |
Thr2 to glutamine | 870 | 12 | 29 |
Thr2 to aspartic acid | 8130 | 1250 | 1110 |
Thr2 to glutamic acid | 5730 | 433 | 468 |
Thr2 to lysine | 1670 | 31 | 70 |
Thr2 to arginine | 5010 | 12 | 28 |
Thr2 to leucine | Â | Â | Â |
Val4 to serine | >2000 | 6.8 | 196 |
Ser38 to alanine | Â | Â | Â |