Angiogenesis in rheumatoid arthritis

Table 1 Examples of molecules that regulate angiogenesis

Effect on angiogenesis	Type of molecule	Molecule
Angiogenic stimuli	Growth factors	FGF-1* and FGF-2, HGF
		Placental growth factor*
		Platelet-derived endothelial-cell growth factor*
		PDGF-BB*
		TGF-α, TGF-β *
		VEGF*
	Cytokines and other mediators	Angiogenin*
		Ang-1*
		Granulocyte-colony-stimulating factor*
		IL-8*
		Midkine, Pleiotrophin
		TNFα*
Angiogenesis inhibitors	Cryptic proteins	Angiostatin (plasminogen fragment)
		Endostatin (collagen XVIII fragment)
		Fibronectin fragment
		Kringle 5 (plasminogen fragment)
		Prolactin 16-kDa fragment
		Vasostatin (calreticulin fragment)
	Cytokines and other mediators	Cartilage-derived inhibitor
		Interferon-inducible protein (IP-10)
		IL-12
		Metalloproteinase inhibitors (TIMPs)
		Plasminogen activator inhibitor
		Platelet factor-4
		Thrombospondin-1

*Expressed in RA. Ang, angiopoietin; FGF, fibroblast growth factor; HGF, hepatocyte growth factor; PDGF, platelet-derived growth factor; TGF, transforming growth factor; VEGF, vascular endothelial growth factor.

ISSN: 1478-6362