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Table 1 Genotypes of experimental animal groups

From: Humanized mice as a model for rheumatoid arthritis

Group Genotype  
1A DR*0401+/human CD4+/Aβ-/-, 18B1/TCR, CoII-HCgp-39, TET-CoII-TNF-α  
1B DR*0401+/human CD4+/Aβ-/-, 18B1/TCR, CoII-HCgp-39 Control group
2A DR*0401+/human CD4+/Aβ-/-, 18B1/TCR, CoII-HCgp-39 HCgp-39 in IFA
2B DR*0401+/human CD4+/Aβ-/-, 18B1/TCR, CoII-HCgp-39 Control group
3A DR*0401+/human CD4+/Aβ-/-, 18B1/TCR, CoII-HCgp-39, Ii-HCgp-39  
3B DR*0401+/human CD4+/Aβ-/-, 18B1/TCR, Ii-HCgp-39  
3C DR*0401+/human CD4+/Aβ-/-, 18B1/TCR Control group
  1. The table shows the detailed genotypes of the different groups of multitransgenic mice that will be used to explore the influence of joint-specific CD4 T cells in the development of inflammatory arthritis in the humanized in vivo mouse model. Coll, collagen type II promoter; HCgp39, human cartilage glycoprotein 39; IFA, incomplete Freund's adjuvant; Ii, invariant chain; TET, tetracycline-inducible TNF-α transgene.