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Table 1 Genotypes of experimental animal groups

From: Humanized mice as a model for rheumatoid arthritis

Group

Genotype

 

1A

DR*0401+/human CD4+/Aβ-/-, 18B1/TCR, CoII-HCgp-39, TET-CoII-TNF-α

 

1B

DR*0401+/human CD4+/Aβ-/-, 18B1/TCR, CoII-HCgp-39

Control group

2A

DR*0401+/human CD4+/Aβ-/-, 18B1/TCR, CoII-HCgp-39

HCgp-39 in IFA

2B

DR*0401+/human CD4+/Aβ-/-, 18B1/TCR, CoII-HCgp-39

Control group

3A

DR*0401+/human CD4+/Aβ-/-, 18B1/TCR, CoII-HCgp-39, Ii-HCgp-39

 

3B

DR*0401+/human CD4+/Aβ-/-, 18B1/TCR, Ii-HCgp-39

 

3C

DR*0401+/human CD4+/Aβ-/-, 18B1/TCR

Control group

  1. The table shows the detailed genotypes of the different groups of multitransgenic mice that will be used to explore the influence of joint-specific CD4 T cells in the development of inflammatory arthritis in the humanized in vivo mouse model. Coll, collagen type II promoter; HCgp39, human cartilage glycoprotein 39; IFA, incomplete Freund's adjuvant; Ii, invariant chain; TET, tetracycline-inducible TNF-α transgene.
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Arthritis Research & Therapy

ISSN: 1478-6362

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