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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Signaling crosstalk between RANKL and interferons in osteoclast differentiation

Figure 1

Signaling crosstalk between RANKL and IFNs. IFN-γ and IFN-β inhibit RANKL signaling by downregulating essential mediators of osteoclastogenesis (TRAF6 and c-Fos, respectively). (See [8, 30], and text for the details). Fra, fos-related antigen; IRF, interferon regulatory factor; ISGF3, interferon-stimulated gene factor-3; JNK, c-Jun N-terminal kinase; NF-κB, nuclear factor κB; OPG, osteoprotegerin; RANK, receptor activator of nuclear factor κB; Stat, signal transducer and activator of transcription; TRAF, TNF receptor-associated factor.

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