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Table 2 Spontaneous murine models of lupus

From: Susceptibility genes in the pathogenesis of murine lupus

Model [reference] Properties
(NZB × NZW)F1, NZM2410, (SWR × NZB)F1 Develops antinuclear autoantibodies and glomerulonephritis that resembles human lupus; exhibits a complex inheritance
MRL/lpr[42], MRL/gld[43] Contains a single-gene mutation (Fas or Fas ligand) that leads to autoimmunity when expressed in MRL background
BXSB/yaa Contains the Y-linked autoimmune accelerator gene that causes a more severe disease in BXSB males