Table 2 Spontaneous murine models of lupus
From: Susceptibility genes in the pathogenesis of murine lupus
Model [reference] | Properties |
|---|---|
(NZB × NZW)F1, NZM2410, (SWR × NZB)F1 | Develops antinuclear autoantibodies and glomerulonephritis that resembles human lupus; exhibits a complex inheritance |
Contains a single-gene mutation (Fas or Fas ligand) that leads to autoimmunity when expressed in MRL background | |
BXSB/yaa | Contains the Y-linked autoimmune accelerator gene that causes a more severe disease in BXSB males |