Table 1 The most-studied components of cartilage matrix
From: The role of structural genes in the pathogenesis of osteoarthritic disorders
| Collagens |
| Types IIa and IIb |
| Type III |
| Type VI |
| Type IX |
| Type X |
| Type XI |
| Type XII |
| Type XIV |
| Proteoglycans |
| Aggrecan |
| Versican |
| Link protein |
| Biglycan (DS-PGI) |
| Decorin (DS-PGII) |
| Epiphycan (DS-PGIII) |
| Fibromodulin |
| Lumican |
| Perlecan |
| Proteoglycan 4 |
| Noncollagenous proteins |
| COMP (cartilage oligomeric matrix protein; thrombospondin-5) |
| CMP (cartilage matrix protein; matrilin-1) |
| Matrilin-3 |
| CILP (cartilage intermediate layer protein) |
| Fibronectin |
| PRELP (proline/arginine-rich and leucine-rich repeat protein) |
| Chondroadherin |
| Fibrillin |
| Tenascin-C |
| Elastin |
| MGP (matrix Gla protein) |
| Chondromodulin-I |
| Chondromodulin-II |
| CD-RAP (cartilage-derived retinoic acid-sensitive protein) |
| ANKH |
| Matrix metalloproteinases and related enxymes |
| Tissue inhibitors of metalloproteinases |