From: The role of structural genes in the pathogenesis of osteoarthritic disorders
Collagens |
Types IIa and IIb |
Type III |
Type VI |
Type IX |
Type X |
Type XI |
Type XII |
Type XIV |
Proteoglycans |
Aggrecan |
Versican |
Link protein |
Biglycan (DS-PGI) |
Decorin (DS-PGII) |
Epiphycan (DS-PGIII) |
Fibromodulin |
Lumican |
Perlecan |
Proteoglycan 4 |
Noncollagenous proteins |
COMP (cartilage oligomeric matrix protein; thrombospondin-5) |
CMP (cartilage matrix protein; matrilin-1) |
Matrilin-3 |
CILP (cartilage intermediate layer protein) |
Fibronectin |
PRELP (proline/arginine-rich and leucine-rich repeat protein) |
Chondroadherin |
Fibrillin |
Tenascin-C |
Elastin |
MGP (matrix Gla protein) |
Chondromodulin-I |
Chondromodulin-II |
CD-RAP (cartilage-derived retinoic acid-sensitive protein) |
ANKH |
Matrix metalloproteinases and related enxymes |
Tissue inhibitors of metalloproteinases |