Table 1 The most-studied components of cartilage matrix

Collagens

   Types IIa and IIb

   Type III

   Type VI

   Type IX

   Type X

   Type XI

   Type XII

   Type XIV

Proteoglycans

   Aggrecan

   Versican

   Link protein

   Biglycan (DS-PGI)

   Decorin (DS-PGII)

   Epiphycan (DS-PGIII)

   Fibromodulin

   Lumican

   Perlecan

   Proteoglycan 4

Noncollagenous proteins

   COMP (cartilage oligomeric matrix protein; thrombospondin-5)

   CMP (cartilage matrix protein; matrilin-1)

   Matrilin-3

   CILP (cartilage intermediate layer protein)

   Fibronectin

   PRELP (proline/arginine-rich and leucine-rich repeat protein)

   Chondroadherin

   Fibrillin

   Tenascin-C

   Elastin

   MGP (matrix Gla protein)

   Chondromodulin-I

   Chondromodulin-II

   CD-RAP (cartilage-derived retinoic acid-sensitive protein)

   ANKH

   Matrix metalloproteinases and related enxymes

   Tissue inhibitors of metalloproteinases